Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs,...

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Detalles Bibliográficos
Autores: Santofimia-Castano, P, Rizzuti, B, Xia, Y, Abian, O, Peng, L, Velazquez-Campoy, A, Iovanna, JL, Neira, JL
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p12803
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/12803
Access Level:acceso abierto
Palabra clave:Drug design
intrinsically disordered protein
molecular dynamics
NUPR1
protein-protein interactions
spectroscopy
Descripción
Sumario:Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs, using it to repurpose drugs for treating pancreatic adenocarcinoma (PDAC).

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