Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.

OBJECTIVES: S100A4 has been recently identified as an adipokine associated with insulin resistance (IR) in adult subjects with obesity. However, no data about its levels in children with obesity and only a few approaches regarding its potential mechanism of action have been reported. To obtain a dee...

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Autores: Taxerås SD, Galán M, Campderros L, Piquer-Garcia I, Pellitero S, Martínez E, Puig R, Lucena I, Tarascó J, Moreno P, Balibrea J, Bel J, Murillo M, Martínez M, Ramon-Krauel M, Puig-Domingo M, Villarroya F, Lerin C, Sánchez-Infantes D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p17469
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17469
Access Level:acceso abierto
Palabra clave:S100A4
insulin resistance
obesity
prepubertal children
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spelling Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.Taxerås SDGalán MCampderros LPiquer-Garcia IPellitero SMartínez EPuig RLucena ITarascó JMoreno PBalibrea JBel JMurillo MMartínez MRamon-Krauel MPuig-Domingo MVillarroya FLerin CSánchez-Infantes DS100A4insulin resistanceobesityprepubertal childrenOBJECTIVES: S100A4 has been recently identified as an adipokine associated with insulin resistance (IR) in adult subjects with obesity. However, no data about its levels in children with obesity and only a few approaches regarding its potential mechanism of action have been reported. To obtain a deeper understanding of the role of S100A4 in obesity, (a) S100A4 levels were measured in prepubertal children and adult subjects with and without obesity and studied the relationship with IR and (b) the effects of S100A4 in cultured human adipocytes and vascular smooth muscle cells (VSMCs) were determined. METHODS: Sixty-five children (50 with obesity, age 9.0 ±1.1 years and 15 normal weight, age 8.4 ±0.8 years) and fifty-nine adults (43 with severe obesity, age 46 ±11 years and 16 normal weight, age 45 ±9 years) were included. Blood from children and adults and adipose tissue samples from adults were obtained and analysed. Human adipocytes and VSMC were incubated with S100A4 to evaluate their response to this adipokine. RESULTS: Circulating S100A4 levels were increased in both children (P = .002) and adults (P < .001) with obesity compared with their normal-weight controls. In subjects with obesity, S100A4 levels were associated with homeostatic model assessment-insulin resistance (HOMA-IR) in adults (ßstd = .42, P = .008) but not in children (ßstd = .12, P = .356). Human adipocytes were not sensitive to S100A4, while incubation with this adipokine significantly reduced inflammatory markers in VSMC. CONCLUSIONS: Our human data demonstrate that higher S100A4 levels are a marker of IR in adults with obesity but not in prepubertal children. Furthermore, the in vitro results suggest that S100A4 might exert an anti-inflammatory effect. Further studies will be necessary to determine whether S100A4 can be a therapeutic target for obesity.WILEY2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17469Obesity Science & PracticeISSN: 20552238reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p174692026-05-27T12:37:41Z
dc.title.none.fl_str_mv Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.
title Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.
spellingShingle Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.
Taxerås SD
S100A4
insulin resistance
obesity
prepubertal children
title_short Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.
title_full Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.
title_fullStr Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.
title_full_unstemmed Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.
title_sort Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.
dc.creator.none.fl_str_mv Taxerås SD
Galán M
Campderros L
Piquer-Garcia I
Pellitero S
Martínez E
Puig R
Lucena I
Tarascó J
Moreno P
Balibrea J
Bel J
Murillo M
Martínez M
Ramon-Krauel M
Puig-Domingo M
Villarroya F
Lerin C
Sánchez-Infantes D
author Taxerås SD
author_facet Taxerås SD
Galán M
Campderros L
Piquer-Garcia I
Pellitero S
Martínez E
Puig R
Lucena I
Tarascó J
Moreno P
Balibrea J
Bel J
Murillo M
Martínez M
Ramon-Krauel M
Puig-Domingo M
Villarroya F
Lerin C
Sánchez-Infantes D
author_role author
author2 Galán M
Campderros L
Piquer-Garcia I
Pellitero S
Martínez E
Puig R
Lucena I
Tarascó J
Moreno P
Balibrea J
Bel J
Murillo M
Martínez M
Ramon-Krauel M
Puig-Domingo M
Villarroya F
Lerin C
Sánchez-Infantes D
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv S100A4
insulin resistance
obesity
prepubertal children
topic S100A4
insulin resistance
obesity
prepubertal children
description OBJECTIVES: S100A4 has been recently identified as an adipokine associated with insulin resistance (IR) in adult subjects with obesity. However, no data about its levels in children with obesity and only a few approaches regarding its potential mechanism of action have been reported. To obtain a deeper understanding of the role of S100A4 in obesity, (a) S100A4 levels were measured in prepubertal children and adult subjects with and without obesity and studied the relationship with IR and (b) the effects of S100A4 in cultured human adipocytes and vascular smooth muscle cells (VSMCs) were determined. METHODS: Sixty-five children (50 with obesity, age 9.0 ±1.1 years and 15 normal weight, age 8.4 ±0.8 years) and fifty-nine adults (43 with severe obesity, age 46 ±11 years and 16 normal weight, age 45 ±9 years) were included. Blood from children and adults and adipose tissue samples from adults were obtained and analysed. Human adipocytes and VSMC were incubated with S100A4 to evaluate their response to this adipokine. RESULTS: Circulating S100A4 levels were increased in both children (P = .002) and adults (P < .001) with obesity compared with their normal-weight controls. In subjects with obesity, S100A4 levels were associated with homeostatic model assessment-insulin resistance (HOMA-IR) in adults (ßstd = .42, P = .008) but not in children (ßstd = .12, P = .356). Human adipocytes were not sensitive to S100A4, while incubation with this adipokine significantly reduced inflammatory markers in VSMC. CONCLUSIONS: Our human data demonstrate that higher S100A4 levels are a marker of IR in adults with obesity but not in prepubertal children. Furthermore, the in vitro results suggest that S100A4 might exert an anti-inflammatory effect. Further studies will be necessary to determine whether S100A4 can be a therapeutic target for obesity.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17469
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17469
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv Obesity Science & Practice
ISSN: 20552238
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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