Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.

[EN]Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins that participate in embr...

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Detalles Bibliográficos
Autores: Wiley, Christopher D, Sharma, Rishi, Davis, Sonnet S, López Domínguez, José Alberto, Mitchell, Kylie P, Wiley, Samantha, Alimirah, Fatouma, Kim, Dong Eun, Payne, Therese, Rosko, Andrew, Aimontche, Eliezer, Deshpande, Sharvari M, Neri, Francesco, Kuehnemann, Chisaka, Demaria, Marco, Ramanathan, Arvind, Campisi, Judith, Wiley, Christopher D., Davis, Sonnet S., Mitchell, Kylie P., Deshpande, Sharvari M.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/166739
Acceso en línea:http://hdl.handle.net/10366/166739
Access Level:acceso abierto
Palabra clave:Cellular senescence
Senolysis
Bioactive lipids
Prostaglandins
2407 Biología Celular
2415 Biología Molecular
2302.21 Biología Molecular
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spelling Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.Wiley, Christopher DSharma, RishiDavis, Sonnet SLópez Domínguez, José AlbertoMitchell, Kylie PWiley, SamanthaAlimirah, FatoumaKim, Dong EunPayne, ThereseRosko, AndrewAimontche, EliezerDeshpande, Sharvari MNeri, FrancescoKuehnemann, ChisakaDemaria, MarcoRamanathan, ArvindCampisi, JudithWiley, Christopher D.Davis, Sonnet S.Mitchell, Kylie P.Deshpande, Sharvari M.Cellular senescenceSenolysisBioactive lipidsProstaglandins2407 Biología Celular2415 Biología Molecular2302.21 Biología Molecular[EN]Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins that participate in embryogenesis, wound healing, inflammation, and many age-related pathologies. By contrast, lipid components of the SASP are understudied. We show that senescent cells activate the biosynthesis of several oxylipins that promote segments of the SASP and reinforce the proliferative arrest. Notably, senescent cells synthesize and accumulate an unstudied intracellular prostaglandin, 1a,1b-dihomo-15-deoxy-delta-12,14-prostaglandin J2. Released 15-deoxy-delta-12,14-prostaglandin J2 is a biomarker of senolysis in culture and in vivo. This and other prostaglandin D2-related lipids promote the senescence arrest and SASP by activating RAS signaling. These data identify an important aspect of cellular senescence and a method to detect senolysis.202520252021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10366/166739reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1667392026-06-07T06:28:51Z
dc.title.none.fl_str_mv Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
title Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
spellingShingle Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
Wiley, Christopher D
Cellular senescence
Senolysis
Bioactive lipids
Prostaglandins
2407 Biología Celular
2415 Biología Molecular
2302.21 Biología Molecular
title_short Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
title_full Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
title_fullStr Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
title_full_unstemmed Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
title_sort Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
dc.creator.none.fl_str_mv Wiley, Christopher D
Sharma, Rishi
Davis, Sonnet S
López Domínguez, José Alberto
Mitchell, Kylie P
Wiley, Samantha
Alimirah, Fatouma
Kim, Dong Eun
Payne, Therese
Rosko, Andrew
Aimontche, Eliezer
Deshpande, Sharvari M
Neri, Francesco
Kuehnemann, Chisaka
Demaria, Marco
Ramanathan, Arvind
Campisi, Judith
Wiley, Christopher D.
Davis, Sonnet S.
Mitchell, Kylie P.
Deshpande, Sharvari M.
author Wiley, Christopher D
author_facet Wiley, Christopher D
Sharma, Rishi
Davis, Sonnet S
López Domínguez, José Alberto
Mitchell, Kylie P
Wiley, Samantha
Alimirah, Fatouma
Kim, Dong Eun
Payne, Therese
Rosko, Andrew
Aimontche, Eliezer
Deshpande, Sharvari M
Neri, Francesco
Kuehnemann, Chisaka
Demaria, Marco
Ramanathan, Arvind
Campisi, Judith
Wiley, Christopher D.
Davis, Sonnet S.
Mitchell, Kylie P.
Deshpande, Sharvari M.
author_role author
author2 Sharma, Rishi
Davis, Sonnet S
López Domínguez, José Alberto
Mitchell, Kylie P
Wiley, Samantha
Alimirah, Fatouma
Kim, Dong Eun
Payne, Therese
Rosko, Andrew
Aimontche, Eliezer
Deshpande, Sharvari M
Neri, Francesco
Kuehnemann, Chisaka
Demaria, Marco
Ramanathan, Arvind
Campisi, Judith
Wiley, Christopher D.
Davis, Sonnet S.
Mitchell, Kylie P.
Deshpande, Sharvari M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cellular senescence
Senolysis
Bioactive lipids
Prostaglandins
2407 Biología Celular
2415 Biología Molecular
2302.21 Biología Molecular
topic Cellular senescence
Senolysis
Bioactive lipids
Prostaglandins
2407 Biología Celular
2415 Biología Molecular
2302.21 Biología Molecular
description [EN]Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins that participate in embryogenesis, wound healing, inflammation, and many age-related pathologies. By contrast, lipid components of the SASP are understudied. We show that senescent cells activate the biosynthesis of several oxylipins that promote segments of the SASP and reinforce the proliferative arrest. Notably, senescent cells synthesize and accumulate an unstudied intracellular prostaglandin, 1a,1b-dihomo-15-deoxy-delta-12,14-prostaglandin J2. Released 15-deoxy-delta-12,14-prostaglandin J2 is a biomarker of senolysis in culture and in vivo. This and other prostaglandin D2-related lipids promote the senescence arrest and SASP by activating RAS signaling. These data identify an important aspect of cellular senescence and a method to detect senolysis.
publishDate 2021
dc.date.none.fl_str_mv 2021
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/166739
url http://hdl.handle.net/10366/166739
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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