Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.

[EN]Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins that participate in embr...

Descripción completa

Detalles Bibliográficos
Autores: Wiley, Christopher D, Sharma, Rishi, Davis, Sonnet S, López Domínguez, José Alberto, Mitchell, Kylie P, Wiley, Samantha, Alimirah, Fatouma, Kim, Dong Eun, Payne, Therese, Rosko, Andrew, Aimontche, Eliezer, Deshpande, Sharvari M, Neri, Francesco, Kuehnemann, Chisaka, Demaria, Marco, Ramanathan, Arvind, Campisi, Judith, Wiley, Christopher D., Davis, Sonnet S., Mitchell, Kylie P., Deshpande, Sharvari M.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/166739
Acceso en línea:http://hdl.handle.net/10366/166739
Access Level:acceso abierto
Palabra clave:Cellular senescence
Senolysis
Bioactive lipids
Prostaglandins
2407 Biología Celular
2415 Biología Molecular
2302.21 Biología Molecular
Descripción
Sumario:[EN]Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins that participate in embryogenesis, wound healing, inflammation, and many age-related pathologies. By contrast, lipid components of the SASP are understudied. We show that senescent cells activate the biosynthesis of several oxylipins that promote segments of the SASP and reinforce the proliferative arrest. Notably, senescent cells synthesize and accumulate an unstudied intracellular prostaglandin, 1a,1b-dihomo-15-deoxy-delta-12,14-prostaglandin J2. Released 15-deoxy-delta-12,14-prostaglandin J2 is a biomarker of senolysis in culture and in vivo. This and other prostaglandin D2-related lipids promote the senescence arrest and SASP by activating RAS signaling. These data identify an important aspect of cellular senescence and a method to detect senolysis.

Similares en LA Referencia