Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study

The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnos...

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Autores: Jimenez-Sousa, Maria Angeles, Liu, Pilar, Medrano, Luz Maria, Fernandez-Rodriguez, Amanda, Almansa, Raquel, Gómez-Sánchez, Esther, Rico, Lucía, Lorenzo, Mario, Fadrique, Alejandra, Tamayo, Eduardo, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/9153
Acceso en línea:http://hdl.handle.net/20.500.12105/9153
Access Level:acceso abierto
Palabra clave:Aged
Alleles
Cardiac Surgical Procedures
Case-Control Studies
European Continental Ancestry Group
Female
Gene Frequency
Genotype
Humans
Lipopolysaccharide Receptors
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
Risk Factors
Sepsis
Shock, Septic
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spelling Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective studyJimenez-Sousa, Maria AngelesLiu, PilarMedrano, Luz MariaFernandez-Rodriguez, AmandaAlmansa, RaquelGómez-Sánchez, EstherRico, LucíaLorenzo, MarioFadrique, AlejandraTamayo, EduardoResino, SalvadorAgedAllelesCardiac Surgical ProceduresCase-Control StudiesEuropean Continental Ancestry GroupFemaleGene FrequencyGenotypeHumansLipopolysaccharide ReceptorsMaleMiddle AgedPolymorphism, Single NucleotideRetrospective StudiesRisk FactorsSepsisShock, SepticThe aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience's MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.Nature Publishing GroupInstituto de Salud Carlos IIIUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Junta de Castilla y León (España)20202020-02-2820182018-01-0120182018-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/9153reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PT13 0001ES PI15 01451ES GRS463 AES 773 AES CT25-ESP01-01 Not availableES CD13 00013ES CD14 00002ES CP14CIII 00010open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/91532026-06-12T12:43:37Z
dc.title.none.fl_str_mv Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
title Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
spellingShingle Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
Jimenez-Sousa, Maria Angeles
Aged
Alleles
Cardiac Surgical Procedures
Case-Control Studies
European Continental Ancestry Group
Female
Gene Frequency
Genotype
Humans
Lipopolysaccharide Receptors
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
Risk Factors
Sepsis
Shock, Septic
title_short Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
title_full Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
title_fullStr Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
title_full_unstemmed Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
title_sort Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study
dc.creator.none.fl_str_mv Jimenez-Sousa, Maria Angeles
Liu, Pilar
Medrano, Luz Maria
Fernandez-Rodriguez, Amanda
Almansa, Raquel
Gómez-Sánchez, Esther
Rico, Lucía
Lorenzo, Mario
Fadrique, Alejandra
Tamayo, Eduardo
Resino, Salvador
author Jimenez-Sousa, Maria Angeles
author_facet Jimenez-Sousa, Maria Angeles
Liu, Pilar
Medrano, Luz Maria
Fernandez-Rodriguez, Amanda
Almansa, Raquel
Gómez-Sánchez, Esther
Rico, Lucía
Lorenzo, Mario
Fadrique, Alejandra
Tamayo, Eduardo
Resino, Salvador
author_role author
author2 Liu, Pilar
Medrano, Luz Maria
Fernandez-Rodriguez, Amanda
Almansa, Raquel
Gómez-Sánchez, Esther
Rico, Lucía
Lorenzo, Mario
Fadrique, Alejandra
Tamayo, Eduardo
Resino, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Junta de Castilla y León (España)
dc.subject.none.fl_str_mv Aged
Alleles
Cardiac Surgical Procedures
Case-Control Studies
European Continental Ancestry Group
Female
Gene Frequency
Genotype
Humans
Lipopolysaccharide Receptors
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
Risk Factors
Sepsis
Shock, Septic
topic Aged
Alleles
Cardiac Surgical Procedures
Case-Control Studies
European Continental Ancestry Group
Female
Gene Frequency
Genotype
Humans
Lipopolysaccharide Receptors
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
Risk Factors
Sepsis
Shock, Septic
description The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience's MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
2020
2020-02-28
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/9153
url http://hdl.handle.net/20.500.12105/9153
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES PT13 0001
ES PI15 01451
ES GRS463 A
ES 773 A
ES CT25-ESP01-01 Not available
ES CD13 00013
ES CD14 00002
ES CP14CIII 00010
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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