Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery

Mesoporous silica nanoparticles have been reported as suitable drug carriers, but their successful delivery to target tissues following systemic administration remains a challenge. In the present work, ultrasound-induced inertial cavitation was evaluated as a mechanism to promote their extravasation...

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Authors: Paris, J.L., Mannaris, Christophoros, Cabañas Criado, María Victoria, Carlisle, Robert, Manzano García, Miguel, Vallet Regí, María Dulce Nombre, Coussios, Constantin C.
Format: article
Publication Date:2017
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/18311
Online Access:https://hdl.handle.net/20.500.14352/18311
Access Level:Open access
Keyword:546
615.46
Extravasation
Nanoparticle Delivery
Cavitation
Mesoporous Silica Nanoparticles
Materiales
Química inorgánica (Farmacia)
Tecnología farmaceútica
3312 Tecnología de Materiales
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oai_identifier_str oai:docta.ucm.es:20.500.14352/18311
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spelling Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug DeliveryParis, J.L.Mannaris, ChristophorosCabañas Criado, María VictoriaCarlisle, RobertManzano García, MiguelVallet Regí, María Dulce NombreCoussios, Constantin C.546615.46ExtravasationNanoparticle DeliveryCavitationMesoporous Silica NanoparticlesMaterialesQuímica inorgánica (Farmacia)Tecnología farmaceútica3312 Tecnología de MaterialesMesoporous silica nanoparticles have been reported as suitable drug carriers, but their successful delivery to target tissues following systemic administration remains a challenge. In the present work, ultrasound-induced inertial cavitation was evaluated as a mechanism to promote their extravasation in a flow-through tissue mimicking agarose phantom. Two different ultrasound frequencies, 0.5 or 1.6 MHz, with pressures in the range 0.5-4 MPa were used to drive cavitation activity which was detected in real time. The optimal ultrasound conditions identified were employed to deliver dye-loaded nanoparticles as a model for drug-loaded nanocarriers, with the level of extravasation evaluated by fluorescence microscopy. The same nanoparticles were then co-injected with submicrometric polymeric cavitation nuclei as a means to promote cavitation activity and decrease the required in-situ acoustic pressure required to attain extravasation. The overall cavitation energy and penetration of the combination was compared to mesoporous silica nanoparticles alone. The results of the present work suggest that combining mesoporous silica nanocarriers and submcrometric cavitation nuclei may help enhance the extravasation of the nanocarrier, thus enabling subsequent sustained drug release to happen from those particles already embedded in the tumour tissue.ElsevierUniversidad Complutense de Madrid20172017-12-1220172017-12-12journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/18311reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/183112026-06-02T12:44:21Z
dc.title.none.fl_str_mv Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
title Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
spellingShingle Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
Paris, J.L.
546
615.46
Extravasation
Nanoparticle Delivery
Cavitation
Mesoporous Silica Nanoparticles
Materiales
Química inorgánica (Farmacia)
Tecnología farmaceútica
3312 Tecnología de Materiales
title_short Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
title_full Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
title_fullStr Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
title_full_unstemmed Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
title_sort Ultrasound-Mediated Cavitation-Enhanced Extravasation of Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery
dc.creator.none.fl_str_mv Paris, J.L.
Mannaris, Christophoros
Cabañas Criado, María Victoria
Carlisle, Robert
Manzano García, Miguel
Vallet Regí, María Dulce Nombre
Coussios, Constantin C.
author Paris, J.L.
author_facet Paris, J.L.
Mannaris, Christophoros
Cabañas Criado, María Victoria
Carlisle, Robert
Manzano García, Miguel
Vallet Regí, María Dulce Nombre
Coussios, Constantin C.
author_role author
author2 Mannaris, Christophoros
Cabañas Criado, María Victoria
Carlisle, Robert
Manzano García, Miguel
Vallet Regí, María Dulce Nombre
Coussios, Constantin C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 546
615.46
Extravasation
Nanoparticle Delivery
Cavitation
Mesoporous Silica Nanoparticles
Materiales
Química inorgánica (Farmacia)
Tecnología farmaceútica
3312 Tecnología de Materiales
topic 546
615.46
Extravasation
Nanoparticle Delivery
Cavitation
Mesoporous Silica Nanoparticles
Materiales
Química inorgánica (Farmacia)
Tecnología farmaceútica
3312 Tecnología de Materiales
description Mesoporous silica nanoparticles have been reported as suitable drug carriers, but their successful delivery to target tissues following systemic administration remains a challenge. In the present work, ultrasound-induced inertial cavitation was evaluated as a mechanism to promote their extravasation in a flow-through tissue mimicking agarose phantom. Two different ultrasound frequencies, 0.5 or 1.6 MHz, with pressures in the range 0.5-4 MPa were used to drive cavitation activity which was detected in real time. The optimal ultrasound conditions identified were employed to deliver dye-loaded nanoparticles as a model for drug-loaded nanocarriers, with the level of extravasation evaluated by fluorescence microscopy. The same nanoparticles were then co-injected with submicrometric polymeric cavitation nuclei as a means to promote cavitation activity and decrease the required in-situ acoustic pressure required to attain extravasation. The overall cavitation energy and penetration of the combination was compared to mesoporous silica nanoparticles alone. The results of the present work suggest that combining mesoporous silica nanocarriers and submcrometric cavitation nuclei may help enhance the extravasation of the nanocarrier, thus enabling subsequent sustained drug release to happen from those particles already embedded in the tumour tissue.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-12-12
2017
2017-12-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/18311
url https://hdl.handle.net/20.500.14352/18311
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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