Amino-acid-based surfactants: New antimicrobial agents

The rapid increase of drug resistant bacteria makes necessary the development of new antimicrobial agents. Synthetic amino acid-based surfactants constitute a promising alternative to conventional antimicrobial compounds given that they can be prepared from renewable raw materials. In this review, w...

Full description

Bibliographic Details
Authors: Pinazo Gassol, Aurora, Manresa Presas, Ma. Ángeles (María Ángeles), Marqués Villavecchia, Ana M., Bustelo, M., Espuny Tomás, Ma. José (María José), Pérez Muñoz, Lourdes
Format: article
Status:Versión aceptada para publicación
Publication Date:2016
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/132741
Online Access:https://hdl.handle.net/2445/132741
Access Level:Open access
Keyword:Agents tensioactius
Tecnologia farmacèutica
Fórmules magistrals
Agents antiinfecciosos
Microbiologia
Aminoàcids
Toxicitat dels medicaments
Surface active agents
Pharmaceutical technology
Medical formularies
Anti-infective agents
Microbiology
Amino acids
Drug toxicity
Description
Summary:The rapid increase of drug resistant bacteria makes necessary the development of new antimicrobial agents. Synthetic amino acid-based surfactants constitute a promising alternative to conventional antimicrobial compounds given that they can be prepared from renewable raw materials. In this review, we discuss the structural features that promote antimicrobial activity of amino acid-based surfactants. Monocatenary, dicatenary and gemini surfactants that contain different amino acids on the polar head and show activity against bacteria are revised. The synthesis and basic physico-chemical properties have also been included.