Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review

Artificial sweeteners are additives widely used in our diet. Although there is no consensus, current evidence indicates that sucralose and saccharin could influence the gut microbiota. The aim of this study was to analyze the existing scientific evidence on the effects of saccharin and sucralose con...

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Detalles Bibliográficos
Autores: Del Pozo de La Calle, Susana, Gómez Martínez, Sonia, Díaz, Ligia E., Nova Rebato, Esther, Urrialde de Andrés, Rafael, Marcos, Ascensión
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/71821
Acceso en línea:https://hdl.handle.net/20.500.14352/71821
Access Level:acceso abierto
Palabra clave:saccharin
sucralose
gut microbiota
acceptable daily intake
short-term studies
long-term studies
short-chain fatty acids
Endocrinología
Gastroenterología y hepatología
Nutrición
3205.02 Endocrinología
3205.03 Gastroenterología
3206 Ciencias de la Nutrición
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network_acronym_str ES
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repository_id_str
spelling Potential Effects of Sucralose and Saccharin on Gut Microbiota: A ReviewDel Pozo de La Calle, SusanaGómez Martínez, SoniaDíaz, Ligia E.Nova Rebato, EstherUrrialde de Andrés, RafaelMarcos, Ascensiónsaccharinsucralosegut microbiotaacceptable daily intakeshort-term studieslong-term studiesshort-chain fatty acidsEndocrinologíaGastroenterología y hepatologíaNutrición3205.02 Endocrinología3205.03 Gastroenterología3206 Ciencias de la NutriciónArtificial sweeteners are additives widely used in our diet. Although there is no consensus, current evidence indicates that sucralose and saccharin could influence the gut microbiota. The aim of this study was to analyze the existing scientific evidence on the effects of saccharin and sucralose consumption on gut microbiota in humans. Different databases were used with the following search terms: sweeteners, non-caloric-sweeteners, sucralose, splenda, saccharin, sugartwin, sweet’n low, microbiota, gut microbiota, humans, animal model, mice, rats, and/or in vitro studies. In vitro and animal model studies indicate a dose-dependent relationship between the intake of both sweeteners and gut microbiota affecting both diversity and composition. In humans, long-term study suggests the existence of a positive correlation between sweetener consumption and some bacterial groups; however, most short-term interventions with saccharin and sucralose, in amounts below the ADI, found no significant effect on those groups, but there seems to be a different basal microbiota-dependent response of metabolic markers. Although studies in vitro and in animal models seem to relate saccharin and sucralose consumption to changes in the gut microbiota, more long-term studies are needed in humans considering the basal microbiota of participants and their dietary and lifestyle habits in all population groups. Toxicological and basal gut microbiota effects must be included as relevant factors to evaluate food safety and nutritional consequences of non-calorie sweeteners. In humans, doses, duration of interventions, and number of subjects included in the studies are key factors to interpret the results.MPDIUniversidad Complutense de Madrid20222022-04-1820222022-04-18journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/71821reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/718212026-06-02T12:44:21Z
dc.title.none.fl_str_mv Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review
title Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review
spellingShingle Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review
Del Pozo de La Calle, Susana
saccharin
sucralose
gut microbiota
acceptable daily intake
short-term studies
long-term studies
short-chain fatty acids
Endocrinología
Gastroenterología y hepatología
Nutrición
3205.02 Endocrinología
3205.03 Gastroenterología
3206 Ciencias de la Nutrición
title_short Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review
title_full Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review
title_fullStr Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review
title_full_unstemmed Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review
title_sort Potential Effects of Sucralose and Saccharin on Gut Microbiota: A Review
dc.creator.none.fl_str_mv Del Pozo de La Calle, Susana
Gómez Martínez, Sonia
Díaz, Ligia E.
Nova Rebato, Esther
Urrialde de Andrés, Rafael
Marcos, Ascensión
author Del Pozo de La Calle, Susana
author_facet Del Pozo de La Calle, Susana
Gómez Martínez, Sonia
Díaz, Ligia E.
Nova Rebato, Esther
Urrialde de Andrés, Rafael
Marcos, Ascensión
author_role author
author2 Gómez Martínez, Sonia
Díaz, Ligia E.
Nova Rebato, Esther
Urrialde de Andrés, Rafael
Marcos, Ascensión
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv saccharin
sucralose
gut microbiota
acceptable daily intake
short-term studies
long-term studies
short-chain fatty acids
Endocrinología
Gastroenterología y hepatología
Nutrición
3205.02 Endocrinología
3205.03 Gastroenterología
3206 Ciencias de la Nutrición
topic saccharin
sucralose
gut microbiota
acceptable daily intake
short-term studies
long-term studies
short-chain fatty acids
Endocrinología
Gastroenterología y hepatología
Nutrición
3205.02 Endocrinología
3205.03 Gastroenterología
3206 Ciencias de la Nutrición
description Artificial sweeteners are additives widely used in our diet. Although there is no consensus, current evidence indicates that sucralose and saccharin could influence the gut microbiota. The aim of this study was to analyze the existing scientific evidence on the effects of saccharin and sucralose consumption on gut microbiota in humans. Different databases were used with the following search terms: sweeteners, non-caloric-sweeteners, sucralose, splenda, saccharin, sugartwin, sweet’n low, microbiota, gut microbiota, humans, animal model, mice, rats, and/or in vitro studies. In vitro and animal model studies indicate a dose-dependent relationship between the intake of both sweeteners and gut microbiota affecting both diversity and composition. In humans, long-term study suggests the existence of a positive correlation between sweetener consumption and some bacterial groups; however, most short-term interventions with saccharin and sucralose, in amounts below the ADI, found no significant effect on those groups, but there seems to be a different basal microbiota-dependent response of metabolic markers. Although studies in vitro and in animal models seem to relate saccharin and sucralose consumption to changes in the gut microbiota, more long-term studies are needed in humans considering the basal microbiota of participants and their dietary and lifestyle habits in all population groups. Toxicological and basal gut microbiota effects must be included as relevant factors to evaluate food safety and nutritional consequences of non-calorie sweeteners. In humans, doses, duration of interventions, and number of subjects included in the studies are key factors to interpret the results.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-04-18
2022
2022-04-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/71821
url https://hdl.handle.net/20.500.14352/71821
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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