Selective antagonism of sigma-1 receptors as a new strategy for pain treatment : behavioural and neurochemical studies
In the present thesis, and in the context of the Sigma-1 receptor (σ1R) research project running at the pharmaceutical company ESTEVE, we addressed, at the preclinical level, the role played by selective σ1R antagonism/blockade in nociception in order to ascertain the therapeutic interest of σ1R ant...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/295458 |
| Acceso en línea: | http://hdl.handle.net/10803/295458 |
| Access Level: | acceso abierto |
| Palabra clave: | Pain Analgesia Sigma Opioid Behavior Microdialysis Dolor Opiacis Microdiàlisi 616.8 |
| Sumario: | In the present thesis, and in the context of the Sigma-1 receptor (σ1R) research project running at the pharmaceutical company ESTEVE, we addressed, at the preclinical level, the role played by selective σ1R antagonism/blockade in nociception in order to ascertain the therapeutic interest of σ1R antagonists in pain treatment. Taking advantage of using selective σ1R pharmacological tools and the in vivo microdialysis technique, the mechanism and the site of action of selective antagonism of σ1R were investigated in pain conditions involving sensitization (formalin model) as well as in acute thermal pain (tail-flick test) to look at the modulation of opioid-induced efficacy and safety-related outcomes. The results of this thesis provide new knowledge about σ1R as a pain target suitable for therapeutic intervention to get analgesia and support the use of σ1R antagonists as opioid adjuvants to treat pain conditions |
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