Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy

The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the associatio...

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Detalles Bibliográficos
Autores: Medrano, Luz M., Gutiérrez-Rivas, Mónica, Blanco, Julià, García, Marcial, Jiménez-Sousa, María A., Pacheco, Yolanda M., Montero, Marta, Iribarren, José A., Bernal, Enrique, Martínez-Madrid, Onofre, Benito, José M., Rallón, Norma, Resino, Salvador
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/387755
Acceso en línea:http://hdl.handle.net/10261/387755
https://api.elsevier.com/content/abstract/scopus_id/85058086740
Access Level:acceso abierto
Palabra clave:mtDNA
HIV
Haplogroups
Immune reconstitution
Mitochondria
cART
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spelling Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapyMedrano, Luz M.Gutiérrez-Rivas, MónicaBlanco, JuliàGarcía, MarcialJiménez-Sousa, María A.Pacheco, Yolanda M.Montero, MartaIribarren, José A.Bernal, EnriqueMartínez-Madrid, OnofreBenito, José M.Rallón, NormaResino, SalvadormtDNAHIVHaplogroupsImmune reconstitutionMitochondriacARTThe mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART.This work has been (partially) funded by Grants RD12/0017/0024 and RD16CIII/0002/0002 to SR, and RD12/0017/0031 and RD16/0025/0013 to JMB as part of the Health Research and Development Strategy, State Plan for Scientific and Technical Research and Innovation (2008–2011; 2013–2016) and co-financed by Institute of Health Carlos III, ISCIII–Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). Luz Mª Medrano is supported by Spanish Carlos III Institute of Health (ISCIII) Madrid, Spain [Grant Number CD14/00002]. N Rallón is a Miguel Servet investigator from the ISCIII [Grant Number CP14/00198]; M. García is a predoctoral student co-funded by CP14/00198 Grant and Intramural Research Scholarship from IIS-FJD.Peer reviewedBioMed CentralInstituto de Salud Carlos IIIEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/387755https://api.elsevier.com/content/abstract/scopus_id/85058086740reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1186/s12967-018-1717-ySíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3877552026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
title Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
spellingShingle Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
Medrano, Luz M.
mtDNA
HIV
Haplogroups
Immune reconstitution
Mitochondria
cART
title_short Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
title_full Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
title_fullStr Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
title_full_unstemmed Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
title_sort Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy
dc.creator.none.fl_str_mv Medrano, Luz M.
Gutiérrez-Rivas, Mónica
Blanco, Julià
García, Marcial
Jiménez-Sousa, María A.
Pacheco, Yolanda M.
Montero, Marta
Iribarren, José A.
Bernal, Enrique
Martínez-Madrid, Onofre
Benito, José M.
Rallón, Norma
Resino, Salvador
author Medrano, Luz M.
author_facet Medrano, Luz M.
Gutiérrez-Rivas, Mónica
Blanco, Julià
García, Marcial
Jiménez-Sousa, María A.
Pacheco, Yolanda M.
Montero, Marta
Iribarren, José A.
Bernal, Enrique
Martínez-Madrid, Onofre
Benito, José M.
Rallón, Norma
Resino, Salvador
author_role author
author2 Gutiérrez-Rivas, Mónica
Blanco, Julià
García, Marcial
Jiménez-Sousa, María A.
Pacheco, Yolanda M.
Montero, Marta
Iribarren, José A.
Bernal, Enrique
Martínez-Madrid, Onofre
Benito, José M.
Rallón, Norma
Resino, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv mtDNA
HIV
Haplogroups
Immune reconstitution
Mitochondria
cART
topic mtDNA
HIV
Haplogroups
Immune reconstitution
Mitochondria
cART
description The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART.
publishDate 2018
dc.date.none.fl_str_mv 2018
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/387755
https://api.elsevier.com/content/abstract/scopus_id/85058086740
url http://hdl.handle.net/10261/387755
https://api.elsevier.com/content/abstract/scopus_id/85058086740
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1186/s12967-018-1717-y
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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