Design and characterization of PLGA nanoparticles with Ferulic Acid and Deferoxamine
Alzheimer’s disease (AD) involves oxidative stress and iron imbalance, both contributing to neuronal degeneration. In this Final Degree Project, poly(lactic- co-glycolic acid) (PLGA) nanoparticles (NPs) were prepared to combine ferulic acid (FA), an antioxidant, and deferoxamine (DFO), an iron chela...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/414004 |
| Acceso en línea: | http://hdl.handle.net/10261/414004 |
| Access Level: | acceso abierto |
| Palabra clave: | Alzheimer’s disease (AD) http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages |
| Sumario: | Alzheimer’s disease (AD) involves oxidative stress and iron imbalance, both contributing to neuronal degeneration. In this Final Degree Project, poly(lactic- co-glycolic acid) (PLGA) nanoparticles (NPs) were prepared to combine ferulic acid (FA), an antioxidant, and deferoxamine (DFO), an iron chelator. The NPs showed a stable colloidal profile, negative ζ-potential, and size below 200 nm, suitable for blood–brain barrier penetration. FA was efficiently encapsulated, while DFO was covalently bound to the NP surface. In SH-SY5Y cells, the formulations showed good biocompatibility and were internalized proportionally to their concentration. Functional assays revealed that FA-loaded NPs reduced H₂O₂-induced oxidative stress, and DFO-functionalized NPs decreased ROS production under iron overload, confirming their complementary protective effects. These results suggest that FA- and DFO-modified PLGA nanoparticles could serve as useful multifunctional tools to reduce oxidative stress and iron imbalance in the early sta |
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