Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618; Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8; Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9; Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45; Burguete, A. (Asunción)|||/items/841509d2-131f-45ab-97cb-0e072035c61e; Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd; Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49; Gil-Royo, A.G. (Ana Gloria)|||/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of...

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Detalles Bibliográficos
Autores:	Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618, Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8, Deharo, E. (Eric)\|\|\|/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9, Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45, Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e, Galiano, S. (Silvia)\|\|\|/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd, Pabon, A. (Adriana)\|\|\|/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49, Gil-Royo, A.G. (Ana Gloria)\|\|\|/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53
Tipo de recurso:	artículo
Fecha de publicación:	2014
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/35725
Acceso en línea:	https://hdl.handle.net/10171/35725
Access Level:	acceso abierto
Palabra clave:	Chalcone Quinoxaline 1,4-di-N-oxide Quinoxaline Antimalarial agents Plasmodium falciparum

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spelling	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agentsAldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8Deharo, E. (Eric)\|\|\|/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61eGaliano, S. (Silvia)\|\|\|/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fdPabon, A. (Adriana)\|\|\|/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49Gil-Royo, A.G. (Ana Gloria)\|\|\|/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53ChalconeQuinoxaline 1,4-di-N-oxideQuinoxalineAntimalarial agentsPlasmodium falciparumWe report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.MDPI (Molecular Diversity Preservation International)Dadun. Depósito Académico Digital Universidad de Navarra20142014-04-0820142014-02-1820142014-02-18journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/35725reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/357252026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
title	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
spellingShingle	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Chalcone Quinoxaline 1,4-di-N-oxide Quinoxaline Antimalarial agents Plasmodium falciparum
title_short	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
title_full	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
title_fullStr	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
title_full_unstemmed	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
title_sort	Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
dc.creator.none.fl_str_mv	Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Deharo, E. (Eric)\|\|\|/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9 Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e Galiano, S. (Silvia)\|\|\|/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd Pabon, A. (Adriana)\|\|\|/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49 Gil-Royo, A.G. (Ana Gloria)\|\|\|/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53
author	Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618
author_facet	Aldana, I. (Ignacio)\|\|\|/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Deharo, E. (Eric)\|\|\|/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9 Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e Galiano, S. (Silvia)\|\|\|/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd Pabon, A. (Adriana)\|\|\|/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49 Gil-Royo, A.G. (Ana Gloria)\|\|\|/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53
author_role	author
author2	Monge, A. (Antonio)\|\|\|/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Deharo, E. (Eric)\|\|\|/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9 Pérez-Silanes, S. (Silvia)\|\|\|/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Burguete, A. (Asunción)\|\|\|/items/841509d2-131f-45ab-97cb-0e072035c61e Galiano, S. (Silvia)\|\|\|/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd Pabon, A. (Adriana)\|\|\|/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49 Gil-Royo, A.G. (Ana Gloria)\|\|\|/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Chalcone Quinoxaline 1,4-di-N-oxide Quinoxaline Antimalarial agents Plasmodium falciparum
topic	Chalcone Quinoxaline 1,4-di-N-oxide Quinoxaline Antimalarial agents Plasmodium falciparum
description	We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.
publishDate	2014
dc.date.none.fl_str_mv	2014 2014-04-08 2014 2014-02-18 2014 2014-02-18
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/35725
url	https://hdl.handle.net/10171/35725
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI (Molecular Diversity Preservation International)
publisher.none.fl_str_mv	MDPI (Molecular Diversity Preservation International)
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.300724

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

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