Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats

The main human concern about the environmental pollutants polybrominated diphenyl ethers (PBDEs) are the rising concentrations accumulated in women. The aim of the present thesis is the study of the toxicity by maternal transference of BDE-99 in the offspring. Among highlights of the results, we fou...

ver descrição completa

Detalhes bibliográficos
Autor: Blanco Pérez, Jordi
Tipo de documento: tese
Estado:Versão publicada
Data de publicação:2013
País:España
Recursos:Universitat Rovira i virgili (URV)
Repositório:Repositori Institucional de la Universitat Rovira i Virgili
OAI Identifier:oai:urv.cat:TDX:1275
Acesso em linha:https://hdl.handle.net/20.500.11797/TDX1275
http://hdl.handle.net/10803/127633
Access Level:Acceso aberto
Palavra-chave:615 - Farmacologia. Terapèutica. Toxicologia. Radiologia
id ES_25d080a8e1ed7a9b387bca5fe2ed32d0
oai_identifier_str oai:urv.cat:TDX:1275
network_acronym_str ES
network_name_str España
repository_id_str
spelling Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal ratsBlanco Pérez, Jordi615 - Farmacologia. Terapèutica. Toxicologia. RadiologiaThe main human concern about the environmental pollutants polybrominated diphenyl ethers (PBDEs) are the rising concentrations accumulated in women. The aim of the present thesis is the study of the toxicity by maternal transference of BDE-99 in the offspring. Among highlights of the results, we found that exposure to BDE-99 during the gestational period produced a delayed ossification, slight hypertrophy of the heart, and enlargement of the liver in rat fetuses. A transplacental effect of BDE-99, evidenced by the activation of nuclear hormones receptors that induce the upregulation of P450 isoforms, was also found in fetal liver correlated with an increase of reactive oxygen substances. Maternal transference of BDE-99 also produced a delay in the spatial learning task and a significant dose-response anxiolytic effect when rat pups were weaned. It was also found that the serum levels of thyroid hormones decreased and signs of hepatoxicity were observed. These results indicate a clear signal of toxicity in rat offspring by BDE-99 at levels comparable to those found in humans.Los contaminantes ambientales difenil éteres polibromados (PBDEs) se encuentran en altas concentraciones en mujeres. El propósito de la presente tesis es el estudio de la toxicidad ocasionada por el traspaso materno de BDE-99 sobre la descendencia. Entre los resultados más destacables, se encontró que la exposición materna al BDE-99 induce toxicidad en fetos de rata causando retraso en la formación de los huesos, ligera hipertrofia de corazón e hígado y fomentando el aumento de producción de substancias reactivas de oxigeno (ROS) en el hígado de los fetos debido a una mayor actividad de las enzimas p450 (CYP). Por otra parte, las crías de rata mostraron un retraso en la tarea de aprendizaje espacial y un efecto ansiolítico de forma dosis-dependiente después de la lactancia. También se encontró que los niveles en suero de hormonas tiroideas disminuyeron y mostraron signos de hapatoxicidad. Estos resultados indican que realmente existe un efecto toxico del contaminante BDE-99 sobre la descendencia de rata a concentraciones encontradas en humanos.Universitat Rovira i Virgili Departament de Ciències Mèdiques BàsiquesUniversitat Rovira i Virgili.2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdf174 p.https://hdl.handle.net/20.500.11797/TDX1275http://hdl.handle.net/10803/127633reponame:Repositori Institucional de la Universitat Rovira i Virgiliinstname:Universitat Rovira i virgili (URV)Inglésinfo:eu-repo/semantics/openAccessADVERTIMENT. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà  indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al repositori institucional de la Universitat Rovira i Virgili. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a aquest repositori (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.oai:urv.cat:TDX:12752026-06-23T12:42:27Z
dc.title.none.fl_str_mv Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats
title Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats
spellingShingle Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats
Blanco Pérez, Jordi
615 - Farmacologia. Terapèutica. Toxicologia. Radiologia
title_short Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats
title_full Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats
title_fullStr Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats
title_full_unstemmed Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats
title_sort Study of thyroid hormone disruption by the environmental contaminant bde-99 in perinatal rats
dc.creator.none.fl_str_mv Blanco Pérez, Jordi
author Blanco Pérez, Jordi
author_facet Blanco Pérez, Jordi
author_role author
dc.contributor.none.fl_str_mv Departament de Ciències Mèdiques Bàsiques
Universitat Rovira i Virgili.
dc.subject.none.fl_str_mv 615 - Farmacologia. Terapèutica. Toxicologia. Radiologia
topic 615 - Farmacologia. Terapèutica. Toxicologia. Radiologia
description The main human concern about the environmental pollutants polybrominated diphenyl ethers (PBDEs) are the rising concentrations accumulated in women. The aim of the present thesis is the study of the toxicity by maternal transference of BDE-99 in the offspring. Among highlights of the results, we found that exposure to BDE-99 during the gestational period produced a delayed ossification, slight hypertrophy of the heart, and enlargement of the liver in rat fetuses. A transplacental effect of BDE-99, evidenced by the activation of nuclear hormones receptors that induce the upregulation of P450 isoforms, was also found in fetal liver correlated with an increase of reactive oxygen substances. Maternal transference of BDE-99 also produced a delay in the spatial learning task and a significant dose-response anxiolytic effect when rat pups were weaned. It was also found that the serum levels of thyroid hormones decreased and signs of hepatoxicity were observed. These results indicate a clear signal of toxicity in rat offspring by BDE-99 at levels comparable to those found in humans.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.11797/TDX1275
http://hdl.handle.net/10803/127633
url https://hdl.handle.net/20.500.11797/TDX1275
http://hdl.handle.net/10803/127633
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
174 p.
dc.publisher.none.fl_str_mv Universitat Rovira i Virgili
publisher.none.fl_str_mv Universitat Rovira i Virgili
dc.source.none.fl_str_mv reponame:Repositori Institucional de la Universitat Rovira i Virgili
instname:Universitat Rovira i virgili (URV)
instname_str Universitat Rovira i virgili (URV)
reponame_str Repositori Institucional de la Universitat Rovira i Virgili
collection Repositori Institucional de la Universitat Rovira i Virgili
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404784498311168
score 15.300724

Registros relacionados