Evaluación de la patogenia experimental y sensibilidad a los antifúngicos de hongos filamentosos
The conventional antifungal therapies commonly used for the treatment of fungal infections due to filamentous fungi are far to be the optimal. These infections can be classified according to their anatomical location in superficial, cutaneous, subcutaneous and systemic. The main objective of this th...
| Autor: | |
|---|---|
| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Universitat Rovira i virgili (URV) |
| Repositorio: | Repositori Institucional de la Universitat Rovira i Virgili |
| OAI Identifier: | oai:urv.cat:TDX:1063 |
| Acceso en línea: | https://hdl.handle.net/20.500.11797/TDX1063 http://hdl.handle.net/10803/81706 |
| Access Level: | acceso abierto |
| Palabra clave: | 615 - Farmacologia. Terapèutica. Toxicologia. Radiologia 579 - Microbiologia |
| Sumario: | The conventional antifungal therapies commonly used for the treatment of fungal infections due to filamentous fungi are far to be the optimal. These infections can be classified according to their anatomical location in superficial, cutaneous, subcutaneous and systemic. The main objective of this thesis was to evaluate both in vitro and in murine models, the efficacy of new therapeutical strategies against a subcutaneous infection such as chromoblastomycosis, and systemic infections such as phaeohyphomycoses and aspergillosis. Posaconazole was the most effective drug in treating experimental infections caused by dematiaceous fungi, i.e. chromoblastomycoses caused by Fonsecaea pedrosoi or Cladophialophora carrionii, and systemic phaeohypomycoses caused by Fonsecaea monophora or Exophiala spp. Anidulafungin, alone and in combination with voriconazole, showed a high efficacy in the treatment of aspergillosis caused by emerging species of the genus Aspergillus, such as Aspergillus flavus and Aspergillus niger. |
|---|