Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.

BACKGROUND: Perceived discrimination is associated with worse mental health. Few studies have assessed whether perceived discrimination (i) is associated with the risk of psychotic disorders and (ii) contributes to an increased risk among minority ethnic groups relative to the ethnic majority. METHO...

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Autores: Misra, Supriya, Gelaye, Bizu, Williams, David R, Koenen, Karestan C, Borba, Christina P C, Quattrone, Diego, Di Forti, Marta, Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Ferraro, Laura, Tarricone, Ilaria, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szoke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Rutten, Bart P F, van Os, Jim, Murray, Robin M, Gayer-Anderson, Charlotte, Morgan, Craig
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15628
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/15628
Access Level:acceso abierto
Palabra clave:Case-control
discrimination
first-episode
minority ethnic group
multi-country
psychosis
psychotic disorder
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spelling Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.Misra, SupriyaGelaye, BizuWilliams, David RKoenen, Karestan CBorba, Christina P CQuattrone, DiegoDi Forti, MartaTripoli, GiadaLa Cascia, CaterinaLa Barbera, DanieleFerraro, LauraTarricone, IlariaBerardi, DomenicoLasalvia, AntonioTosato, SarahSzoke, AndreiLlorca, Pierre-MichelArango, CelsoTortelli, Andreade Haan, LieuweVelthorst, EvaBobes, JulioBernardo, MiguelSanjuan, JulioSantos, Jose LuisArrojo, ManuelDel-Ben, Cristina MartaMenezes, Paulo RossiSelten, Jean-PaulJones, Peter BJongsma, Hannah EKirkbride, James BRutten, Bart P Fvan Os, JimMurray, Robin MGayer-Anderson, CharlotteMorgan, CraigCase-controldiscriminationfirst-episodeminority ethnic groupmulti-countrypsychosispsychotic disorderBACKGROUND: Perceived discrimination is associated with worse mental health. Few studies have assessed whether perceived discrimination (i) is associated with the risk of psychotic disorders and (ii) contributes to an increased risk among minority ethnic groups relative to the ethnic majority. METHODS: We used data from the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2, a population-based case-control study of incident psychotic disorders in 17 catchment sites across six countries. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for the associations between perceived discrimination and psychosis using mixed-effects logistic regression models. We used stratified and mediation analyses to explore differences for minority ethnic groups. RESULTS: Reporting any perceived experience of major discrimination (e.g. unfair treatment by police, not getting hired) was higher in cases than controls (41.8% v. 34.2%). Pervasive experiences of discrimination (=3 types) were also higher in cases than controls (11.3% v. 5.5%). In fully adjusted models, the odds of psychosis were 1.20 (95% CI 0.91-1.59) for any discrimination and 1.79 (95% CI 1.19-1.59) for pervasive discrimination compared with no discrimination. In stratified analyses, the magnitude of association for pervasive experiences of discrimination appeared stronger for minority ethnic groups (OR = 1.73, 95% CI 1.12-2.68) than the ethnic majority (OR = 1.42, 95% CI 0.65-3.10). In exploratory mediation analysis, pervasive discrimination minimally explained excess risk among minority ethnic groups (5.1%). CONCLUSIONS: Pervasive experiences of discrimination are associated with slightly increased odds of psychotic disorders and may minimally help explain excess risk for minority ethnic groups.CAMBRIDGE UNIV PRESS2021info:eu-repo/semantics/articleaheadOfPrintVersionhttps://incliva.portalinvestigacion.com/publicaciones/15628PSYCHOLOGICAL MEDICINEISSN: 00332917ISSNe: 14698978reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p156282026-06-07T16:35:31Z
dc.title.none.fl_str_mv Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
title Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
spellingShingle Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
Misra, Supriya
Case-control
discrimination
first-episode
minority ethnic group
multi-country
psychosis
psychotic disorder
title_short Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
title_full Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
title_fullStr Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
title_full_unstemmed Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
title_sort Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
dc.creator.none.fl_str_mv Misra, Supriya
Gelaye, Bizu
Williams, David R
Koenen, Karestan C
Borba, Christina P C
Quattrone, Diego
Di Forti, Marta
Tripoli, Giada
La Cascia, Caterina
La Barbera, Daniele
Ferraro, Laura
Tarricone, Ilaria
Berardi, Domenico
Lasalvia, Antonio
Tosato, Sarah
Szoke, Andrei
Llorca, Pierre-Michel
Arango, Celso
Tortelli, Andrea
de Haan, Lieuwe
Velthorst, Eva
Bobes, Julio
Bernardo, Miguel
Sanjuan, Julio
Santos, Jose Luis
Arrojo, Manuel
Del-Ben, Cristina Marta
Menezes, Paulo Rossi
Selten, Jean-Paul
Jones, Peter B
Jongsma, Hannah E
Kirkbride, James B
Rutten, Bart P F
van Os, Jim
Murray, Robin M
Gayer-Anderson, Charlotte
Morgan, Craig
author Misra, Supriya
author_facet Misra, Supriya
Gelaye, Bizu
Williams, David R
Koenen, Karestan C
Borba, Christina P C
Quattrone, Diego
Di Forti, Marta
Tripoli, Giada
La Cascia, Caterina
La Barbera, Daniele
Ferraro, Laura
Tarricone, Ilaria
Berardi, Domenico
Lasalvia, Antonio
Tosato, Sarah
Szoke, Andrei
Llorca, Pierre-Michel
Arango, Celso
Tortelli, Andrea
de Haan, Lieuwe
Velthorst, Eva
Bobes, Julio
Bernardo, Miguel
Sanjuan, Julio
Santos, Jose Luis
Arrojo, Manuel
Del-Ben, Cristina Marta
Menezes, Paulo Rossi
Selten, Jean-Paul
Jones, Peter B
Jongsma, Hannah E
Kirkbride, James B
Rutten, Bart P F
van Os, Jim
Murray, Robin M
Gayer-Anderson, Charlotte
Morgan, Craig
author_role author
author2 Gelaye, Bizu
Williams, David R
Koenen, Karestan C
Borba, Christina P C
Quattrone, Diego
Di Forti, Marta
Tripoli, Giada
La Cascia, Caterina
La Barbera, Daniele
Ferraro, Laura
Tarricone, Ilaria
Berardi, Domenico
Lasalvia, Antonio
Tosato, Sarah
Szoke, Andrei
Llorca, Pierre-Michel
Arango, Celso
Tortelli, Andrea
de Haan, Lieuwe
Velthorst, Eva
Bobes, Julio
Bernardo, Miguel
Sanjuan, Julio
Santos, Jose Luis
Arrojo, Manuel
Del-Ben, Cristina Marta
Menezes, Paulo Rossi
Selten, Jean-Paul
Jones, Peter B
Jongsma, Hannah E
Kirkbride, James B
Rutten, Bart P F
van Os, Jim
Murray, Robin M
Gayer-Anderson, Charlotte
Morgan, Craig
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Case-control
discrimination
first-episode
minority ethnic group
multi-country
psychosis
psychotic disorder
topic Case-control
discrimination
first-episode
minority ethnic group
multi-country
psychosis
psychotic disorder
description BACKGROUND: Perceived discrimination is associated with worse mental health. Few studies have assessed whether perceived discrimination (i) is associated with the risk of psychotic disorders and (ii) contributes to an increased risk among minority ethnic groups relative to the ethnic majority. METHODS: We used data from the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2, a population-based case-control study of incident psychotic disorders in 17 catchment sites across six countries. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for the associations between perceived discrimination and psychosis using mixed-effects logistic regression models. We used stratified and mediation analyses to explore differences for minority ethnic groups. RESULTS: Reporting any perceived experience of major discrimination (e.g. unfair treatment by police, not getting hired) was higher in cases than controls (41.8% v. 34.2%). Pervasive experiences of discrimination (=3 types) were also higher in cases than controls (11.3% v. 5.5%). In fully adjusted models, the odds of psychosis were 1.20 (95% CI 0.91-1.59) for any discrimination and 1.79 (95% CI 1.19-1.59) for pervasive discrimination compared with no discrimination. In stratified analyses, the magnitude of association for pervasive experiences of discrimination appeared stronger for minority ethnic groups (OR = 1.73, 95% CI 1.12-2.68) than the ethnic majority (OR = 1.42, 95% CI 0.65-3.10). In exploratory mediation analysis, pervasive discrimination minimally explained excess risk among minority ethnic groups (5.1%). CONCLUSIONS: Pervasive experiences of discrimination are associated with slightly increased odds of psychotic disorders and may minimally help explain excess risk for minority ethnic groups.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
aheadOfPrintVersion
format article
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/15628
url https://incliva.portalinvestigacion.com/publicaciones/15628
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
dc.source.none.fl_str_mv PSYCHOLOGICAL MEDICINE
ISSN: 00332917
ISSNe: 14698978
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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