Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.

BACKGROUND: Perceived discrimination is associated with worse mental health. Few studies have assessed whether perceived discrimination (i) is associated with the risk of psychotic disorders and (ii) contributes to an increased risk among minority ethnic groups relative to the ethnic majority. METHO...

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Detalles Bibliográficos
Autores: Misra, Supriya, Gelaye, Bizu, Williams, David R, Koenen, Karestan C, Borba, Christina P C, Quattrone, Diego, Di Forti, Marta, Tripoli, Giada, La Cascia, Caterina, La Barbera, Daniele, Ferraro, Laura, Tarricone, Ilaria, Berardi, Domenico, Lasalvia, Antonio, Tosato, Sarah, Szoke, Andrei, Llorca, Pierre-Michel, Arango, Celso, Tortelli, Andrea, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Rutten, Bart P F, van Os, Jim, Murray, Robin M, Gayer-Anderson, Charlotte, Morgan, Craig
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15628
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/15628
Access Level:acceso abierto
Palabra clave:Case-control
discrimination
first-episode
minority ethnic group
multi-country
psychosis
psychotic disorder
Descripción
Sumario:BACKGROUND: Perceived discrimination is associated with worse mental health. Few studies have assessed whether perceived discrimination (i) is associated with the risk of psychotic disorders and (ii) contributes to an increased risk among minority ethnic groups relative to the ethnic majority. METHODS: We used data from the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2, a population-based case-control study of incident psychotic disorders in 17 catchment sites across six countries. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for the associations between perceived discrimination and psychosis using mixed-effects logistic regression models. We used stratified and mediation analyses to explore differences for minority ethnic groups. RESULTS: Reporting any perceived experience of major discrimination (e.g. unfair treatment by police, not getting hired) was higher in cases than controls (41.8% v. 34.2%). Pervasive experiences of discrimination (=3 types) were also higher in cases than controls (11.3% v. 5.5%). In fully adjusted models, the odds of psychosis were 1.20 (95% CI 0.91-1.59) for any discrimination and 1.79 (95% CI 1.19-1.59) for pervasive discrimination compared with no discrimination. In stratified analyses, the magnitude of association for pervasive experiences of discrimination appeared stronger for minority ethnic groups (OR = 1.73, 95% CI 1.12-2.68) than the ethnic majority (OR = 1.42, 95% CI 0.65-3.10). In exploratory mediation analysis, pervasive discrimination minimally explained excess risk among minority ethnic groups (5.1%). CONCLUSIONS: Pervasive experiences of discrimination are associated with slightly increased odds of psychotic disorders and may minimally help explain excess risk for minority ethnic groups.

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