Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-me...
| Authors: | , , |
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| Format: | article |
| Publication Date: | 2007 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/17456 |
| Online Access: | http://hdl.handle.net/20.500.12105/17456 |
| Access Level: | Open access |
| Keyword: | Neoplasm Invasiveness Cadherins Cell Adhesion Cell Movement Disease Progression Epithelium Helix-Turn-Helix Motifs Homeodomain Proteins Humans Models, Biological Neoplasms Phenotype Protein Processing, Post-Translational Repressor Proteins Signal Transduction Snail Family Transcription Factors Transcription Factors Zinc Finger E-box-Binding Homeobox 1 |
| Summary: | The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications. |
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