RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons

Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically distributed to support their function. Subcellular protein distribution is typica...

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Autores: Blanco Urrejola, Maite, Gaminde Blasco, Adhara Mikaela, Gamarra, María, De la Cruz Gambra, Aida, Vecino Cordero, Elena, Alberdi Alfonso, Elena María, Baleriola, Jimena
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/50834
Acceso en línea:http://hdl.handle.net/10810/50834
Access Level:acceso abierto
Palabra clave:mRNA transport and localization
local protein synthesis
neurons
neurites
glia
processes
neurological and neurodegenerative diseases
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spelling RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from NeuronsBlanco Urrejola, MaiteGaminde Blasco, Adhara MikaelaGamarra, MaríaDe la Cruz Gambra, AidaVecino Cordero, ElenaAlberdi Alfonso, Elena MaríaBaleriola, JimenamRNA transport and localizationlocal protein synthesisneuronsneuritesgliaprocessesneurological and neurodegenerative diseasesCell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically distributed to support their function. Subcellular protein distribution is typically achieved by localization peptides within the protein sequence. However, protein delivery to distinct cellular compartments can rely, not only on the transport of the protein itself but also on the transport of the mRNA that is then translated at target sites. This phenomenon is known as local protein synthesis. Local protein synthesis relies on the transport of mRNAs to subcellular domains and their translation to proteins at target sites by the also localized translation machinery. Neurons and glia specially depend upon the accurate subcellular distribution of their proteome to fulfil their polarized functions. In this sense, local protein synthesis has revealed itself as a crucial mechanism that regulates proper protein homeostasis in subcellular compartments. Thus, deregulation of mRNA transport and/or of localized translation can lead to neurological and neurodegenerative diseases. Local translation has been more extensively studied in neurons than in glia. In this review article, we will summarize the state-of-the art research on local protein synthesis in neuronal function and dysfunction, and we will discuss the possibility that local translation in glia and deregulation thereof contributes to neurological and neurodegenerative diseases.This paper was partially funded by grants awarded to J.B. (MICINN grants SAF2016-76347-R, RYC-2016-19837 and PID2019-110721RB-I00; The Alzheimer’s Association grant AARG-19-618303) and E.A. (MICINN grant PID2019-108465RB-I00; Basque Government grant PIBA-2020-1-0012). M.B.-U. is a UPV/EHU fellow; A.G.-B. is a FPU (FPU17/04891) fellow; M.G. and A.d.l.C. are GV fellows.MDPI2021202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/50834reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/SAF2016-76347-R/info:eu-repo/grantAgreement/MICINN/RYC-2016-19837/info:eu-repo/grantAgreement/MICINN/PID2019-110721RB-I00/info:eu-repo/grantAgreement/MICINN/PID2019-108465RB-I00/https://www.mdpi.com/2073-4409/10/3/632/htminfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/508342026-06-18T09:23:17Z
dc.title.none.fl_str_mv RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
title RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
spellingShingle RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
Blanco Urrejola, Maite
mRNA transport and localization
local protein synthesis
neurons
neurites
glia
processes
neurological and neurodegenerative diseases
title_short RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
title_full RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
title_fullStr RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
title_full_unstemmed RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
title_sort RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
dc.creator.none.fl_str_mv Blanco Urrejola, Maite
Gaminde Blasco, Adhara Mikaela
Gamarra, María
De la Cruz Gambra, Aida
Vecino Cordero, Elena
Alberdi Alfonso, Elena María
Baleriola, Jimena
author Blanco Urrejola, Maite
author_facet Blanco Urrejola, Maite
Gaminde Blasco, Adhara Mikaela
Gamarra, María
De la Cruz Gambra, Aida
Vecino Cordero, Elena
Alberdi Alfonso, Elena María
Baleriola, Jimena
author_role author
author2 Gaminde Blasco, Adhara Mikaela
Gamarra, María
De la Cruz Gambra, Aida
Vecino Cordero, Elena
Alberdi Alfonso, Elena María
Baleriola, Jimena
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv mRNA transport and localization
local protein synthesis
neurons
neurites
glia
processes
neurological and neurodegenerative diseases
topic mRNA transport and localization
local protein synthesis
neurons
neurites
glia
processes
neurological and neurodegenerative diseases
description Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically distributed to support their function. Subcellular protein distribution is typically achieved by localization peptides within the protein sequence. However, protein delivery to distinct cellular compartments can rely, not only on the transport of the protein itself but also on the transport of the mRNA that is then translated at target sites. This phenomenon is known as local protein synthesis. Local protein synthesis relies on the transport of mRNAs to subcellular domains and their translation to proteins at target sites by the also localized translation machinery. Neurons and glia specially depend upon the accurate subcellular distribution of their proteome to fulfil their polarized functions. In this sense, local protein synthesis has revealed itself as a crucial mechanism that regulates proper protein homeostasis in subcellular compartments. Thus, deregulation of mRNA transport and/or of localized translation can lead to neurological and neurodegenerative diseases. Local translation has been more extensively studied in neurons than in glia. In this review article, we will summarize the state-of-the art research on local protein synthesis in neuronal function and dysfunction, and we will discuss the possibility that local translation in glia and deregulation thereof contributes to neurological and neurodegenerative diseases.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/50834
url http://hdl.handle.net/10810/50834
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/SAF2016-76347-R/
info:eu-repo/grantAgreement/MICINN/RYC-2016-19837/
info:eu-repo/grantAgreement/MICINN/PID2019-110721RB-I00/
info:eu-repo/grantAgreement/MICINN/PID2019-108465RB-I00/
https://www.mdpi.com/2073-4409/10/3/632/htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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