Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration

Inherited retinal dystrophies (IRDs) are a broad group of neurodegenerative disorders associated with reduced or deteriorating visual system. In the retina, cells are under constant oxidative stress, leading to elevated reactive oxygen species (ROS) generation that induces mitochondrial dysfunction...

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Detalles Bibliográficos
Autores: Mirra, Serena, Marfany i Nadal, Gemma
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/196046
Acceso en línea:https://hdl.handle.net/2445/196046
Access Level:acceso abierto
Palabra clave:Malalties de la retina
Retinopatia diabètica
Estrès oxidatiu
Retinal diseases
Diabetic retinopathy
Oxidative stress
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spelling Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegenerationMirra, SerenaMarfany i Nadal, GemmaMalalties de la retinaRetinopatia diabèticaEstrès oxidatiuRetinal diseasesDiabetic retinopathyOxidative stressInherited retinal dystrophies (IRDs) are a broad group of neurodegenerative disorders associated with reduced or deteriorating visual system. In the retina, cells are under constant oxidative stress, leading to elevated reactive oxygen species (ROS) generation that induces mitochondrial dysfunction and alteration of the mitochondrial network. This mitochondrial dysfunction combined with mutations in mitochondrial DNA and nuclear genes makes photoreceptors and retinal ganglion cells more susceptible to cell death. In this minireview, we focus on mitochondrial dynamics and their contribution to neuronal degeneration underlying IRDs, with particular attention to Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA), and propose targeting cell resilience and mitochondrial dynamics modulators as potential therapeutic approaches for retinal disorders.Springer Verlag2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/196046Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1007/978-3-030-27378-1_84Advances in Experimental Medicine and Biology, 2019, vol. 1185, p. 513-517https://doi.org/10.1007/978-3-030-27378-1_84(c) Springer Verlag, 2019info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1960462026-05-27T06:46:51Z
dc.title.none.fl_str_mv Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration
title Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration
spellingShingle Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration
Mirra, Serena
Malalties de la retina
Retinopatia diabètica
Estrès oxidatiu
Retinal diseases
Diabetic retinopathy
Oxidative stress
title_short Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration
title_full Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration
title_fullStr Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration
title_full_unstemmed Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration
title_sort Mitochondrial gymnastics in retinal cells: a resilience mechanism against oxidative stress and neurodegeneration
dc.creator.none.fl_str_mv Mirra, Serena
Marfany i Nadal, Gemma
author Mirra, Serena
author_facet Mirra, Serena
Marfany i Nadal, Gemma
author_role author
author2 Marfany i Nadal, Gemma
author2_role author
dc.subject.none.fl_str_mv Malalties de la retina
Retinopatia diabètica
Estrès oxidatiu
Retinal diseases
Diabetic retinopathy
Oxidative stress
topic Malalties de la retina
Retinopatia diabètica
Estrès oxidatiu
Retinal diseases
Diabetic retinopathy
Oxidative stress
description Inherited retinal dystrophies (IRDs) are a broad group of neurodegenerative disorders associated with reduced or deteriorating visual system. In the retina, cells are under constant oxidative stress, leading to elevated reactive oxygen species (ROS) generation that induces mitochondrial dysfunction and alteration of the mitochondrial network. This mitochondrial dysfunction combined with mutations in mitochondrial DNA and nuclear genes makes photoreceptors and retinal ganglion cells more susceptible to cell death. In this minireview, we focus on mitochondrial dynamics and their contribution to neuronal degeneration underlying IRDs, with particular attention to Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA), and propose targeting cell resilience and mitochondrial dynamics modulators as potential therapeutic approaches for retinal disorders.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/196046
url https://hdl.handle.net/2445/196046
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1007/978-3-030-27378-1_84
Advances in Experimental Medicine and Biology, 2019, vol. 1185, p. 513-517
https://doi.org/10.1007/978-3-030-27378-1_84
dc.rights.none.fl_str_mv (c) Springer Verlag, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Verlag, 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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