Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia

Stenotrophomonas maltophilia is an opportunistic Gram-negative pathogen with increasing incidence in clinical settings. The most critical aspect of S. maltophilia is its frequent resistance to a majority of the antibiotics of clinical use. Quorum Sensing (QS) systems coordinate bacterial populations...

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Authors: Huedo Moreno, Pol|||0000-0002-2933-0586, Coves, Xavier|||0000-0002-8970-8907, Daura i Ribera, Xavier|||0000-0001-9235-6730, Gibert, Isidre|||0000-0003-1442-2258, Yero, Daniel|||0000-0002-6234-4082
Format: article
Publication Date:2018
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:190816
Online Access:https://ddd.uab.cat/record/190816
https://dx.doi.org/urn:doi:10.3389/fcimb.2018.00122
Access Level:Open access
Keyword:Multi-drug resistance
Quorum sensing
Quorum quenching
Nosocomial infections
Antimicrobial resistance
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spelling Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophiliaHuedo Moreno, Pol|||0000-0002-2933-0586Coves, Xavier|||0000-0002-8970-8907Daura i Ribera, Xavier|||0000-0001-9235-6730Gibert, Isidre|||0000-0003-1442-2258Yero, Daniel|||0000-0002-6234-4082Multi-drug resistanceQuorum sensingQuorum quenchingNosocomial infectionsAntimicrobial resistanceStenotrophomonas maltophilia is an opportunistic Gram-negative pathogen with increasing incidence in clinical settings. The most critical aspect of S. maltophilia is its frequent resistance to a majority of the antibiotics of clinical use. Quorum Sensing (QS) systems coordinate bacterial populations and act as major regulatory mechanisms of pathogenesis in both pure cultures and poly-microbial communities. Disruption of QS systems, a phenomenon known as Quorum Quenching (QQ), represents a new promising paradigm for the design of novel antimicrobial strategies. In this context, we review the main advances in the field of QS in S. maltophilia by paying special attention to Diffusible Signal Factor (DSF) signaling, Acyl Homoserine Lactone (AHL) responses and the controversial Ax21 system. Advances in the DSF system include regulatory aspects of DSF synthesis and perception by both rpf -1 and rpf -2 variant systems, as well as their reciprocal communication. Interaction via DSF of S. maltophilia with unrelated organisms including bacteria, yeast and plants is also considered. Finally, an overview of the different QQ mechanisms involving S. maltophilia as quencher and as object of quenching is presented, revealing the potential of this species for use in QQ applications. This review provides a comprehensive snapshot of the interconnected QS network that S. maltophilia uses to sense and respond to its surrounding biotic or abiotic environment. Understanding such cooperative and competitive communication mechanisms is essential for the design of effective anti QS strategies. 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/190816https://dx.doi.org/urn:doi:10.3389/fcimb.2018.00122reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2015-66674-RAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-1280open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1908162026-06-06T12:50:31Z
dc.title.none.fl_str_mv Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia
title Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia
spellingShingle Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia
Huedo Moreno, Pol|||0000-0002-2933-0586
Multi-drug resistance
Quorum sensing
Quorum quenching
Nosocomial infections
Antimicrobial resistance
title_short Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia
title_full Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia
title_fullStr Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia
title_full_unstemmed Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia
title_sort Quorum sensing signaling and quenching in the multidrug-resistant pathogen stenotrophomonas maltophilia
dc.creator.none.fl_str_mv Huedo Moreno, Pol|||0000-0002-2933-0586
Coves, Xavier|||0000-0002-8970-8907
Daura i Ribera, Xavier|||0000-0001-9235-6730
Gibert, Isidre|||0000-0003-1442-2258
Yero, Daniel|||0000-0002-6234-4082
author Huedo Moreno, Pol|||0000-0002-2933-0586
author_facet Huedo Moreno, Pol|||0000-0002-2933-0586
Coves, Xavier|||0000-0002-8970-8907
Daura i Ribera, Xavier|||0000-0001-9235-6730
Gibert, Isidre|||0000-0003-1442-2258
Yero, Daniel|||0000-0002-6234-4082
author_role author
author2 Coves, Xavier|||0000-0002-8970-8907
Daura i Ribera, Xavier|||0000-0001-9235-6730
Gibert, Isidre|||0000-0003-1442-2258
Yero, Daniel|||0000-0002-6234-4082
author2_role author
author
author
author
dc.subject.none.fl_str_mv Multi-drug resistance
Quorum sensing
Quorum quenching
Nosocomial infections
Antimicrobial resistance
topic Multi-drug resistance
Quorum sensing
Quorum quenching
Nosocomial infections
Antimicrobial resistance
description Stenotrophomonas maltophilia is an opportunistic Gram-negative pathogen with increasing incidence in clinical settings. The most critical aspect of S. maltophilia is its frequent resistance to a majority of the antibiotics of clinical use. Quorum Sensing (QS) systems coordinate bacterial populations and act as major regulatory mechanisms of pathogenesis in both pure cultures and poly-microbial communities. Disruption of QS systems, a phenomenon known as Quorum Quenching (QQ), represents a new promising paradigm for the design of novel antimicrobial strategies. In this context, we review the main advances in the field of QS in S. maltophilia by paying special attention to Diffusible Signal Factor (DSF) signaling, Acyl Homoserine Lactone (AHL) responses and the controversial Ax21 system. Advances in the DSF system include regulatory aspects of DSF synthesis and perception by both rpf -1 and rpf -2 variant systems, as well as their reciprocal communication. Interaction via DSF of S. maltophilia with unrelated organisms including bacteria, yeast and plants is also considered. Finally, an overview of the different QQ mechanisms involving S. maltophilia as quencher and as object of quenching is presented, revealing the potential of this species for use in QQ applications. This review provides a comprehensive snapshot of the interconnected QS network that S. maltophilia uses to sense and respond to its surrounding biotic or abiotic environment. Understanding such cooperative and competitive communication mechanisms is essential for the design of effective anti QS strategies.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/190816
https://dx.doi.org/urn:doi:10.3389/fcimb.2018.00122
url https://ddd.uab.cat/record/190816
https://dx.doi.org/urn:doi:10.3389/fcimb.2018.00122
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2015-66674-R
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-1280
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/3.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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