Discrepancies in assessing intellectual disability levels in adults with Down syndrome: Implications for dementia diagnosis

INTRODUCTIONCut-offs derived from baseline cognitive assessments, stratified by intellectual disability (ID) level, have been proposed to diagnose symptomatic Alzheimer's disease (AD) in Down syndrome (DS). However, discrepancies in ID classification risk misclassification when applying cut-off...

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Detalles Bibliográficos
Autores: Soriano, LD, Sandkühler, K, Videla, L, Benejam, B, Carmona-Iragui, M, Wlasich, E, Kustermann, J, Barroeta, I, Vaqué-Alcázar, L, Rodríguez-Baz, I, Bejanin, A, Fernández, S, Arranz, J, Arriola-Infante, JE, Maure-Blesa, L, Juan, AS, Nübling, G, Wagemann, O, Stockbauer, A, Hassenstab, J, Levin, J, Fortea, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19813
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19813
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
AD21
Cambridge Cognitive Examination for Older Adults with Down Syndrome
cut-off points
dementia
diagnostic performance
Down Alzheimer Barcelona Neuroimaging Initiative
Down syndrome
Down syndrome-associated Alzheimer's disease
intellectual disability
Descripción
Sumario:INTRODUCTIONCut-offs derived from baseline cognitive assessments, stratified by intellectual disability (ID) level, have been proposed to diagnose symptomatic Alzheimer's disease (AD) in Down syndrome (DS). However, discrepancies in ID classification risk misclassification when applying cut-offs across sites. METHODSThis dual-center cohort study included 673 adults with mild to moderate ID at different AD stages. We assessed ID classification discrepancies across sites and the impact on Cambridge Cognitive Examination for Older Adults with Down's Syndrome (CAMCOG-DS) cut-offs for AD dementia diagnosis derived from receiver operating characteristic analysis. RESULTSInter-rater agreement for ID level classification was 95% within sites but 60% between sites. While CAMCOG-DS score distributions in the whole cohort were similar across sites, ID classification discrepancies caused higher cut-offs in Barcelona for mild and moderate ID compared to Munich. Applying site-specific cut-offs to another cohort reduced sensitivity and specificity. DISCUSSIONStandardizing ID classification is critical for generalizable cut-offs to accurately diagnose AD dementia based on neuropsychological assessments in DS.

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