Caracterización transcriptómica del cáncer de endometrio y su importancia en el diseño de nuevas estrategias terapéuticas
Endometrial cancer is the most frequent gynecological tumor in development countries. Currently there is a lack of therapeutic options in this type of tumors, which gives rise to a great interest in the search for therapeutic targets that allows the treatment to be customized for the benefit of the...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Oberta de Catalunya (UOC) |
| Repositorio: | O2, repositorio institucional de la UOC |
| OAI Identifier: | oai:openaccess.uoc.edu:10609/82726 |
| Acceso en línea: | http://hdl.handle.net/10609/82726 |
| Access Level: | acceso abierto |
| Palabra clave: | RNA-seq endometrial cancer targeted therapy cáncer de endometrio terapia dirigida càncer d'endometri teràpia dirigida Bioinformatics -- TFM Bioinformàtica -- TFM Bioinformática -- TFM |
| Sumario: | Endometrial cancer is the most frequent gynecological tumor in development countries. Currently there is a lack of therapeutic options in this type of tumors, which gives rise to a great interest in the search for therapeutic targets that allows the treatment to be customized for the benefit of the patient. The objective of the project was to find out significant differences in the expression of the genes in patients with MSI-H endometrial cancer against MSI-L and MSS, with the objective of finding possible therapeutics options. Methods: To carry out the study, data were obtained from the RNA-seq analysis of samples from patients with TCGA endometrial cancer. The differential expression analysis was carried out using the limma package. Subsequently an analysis of pathway enrichment and gene co-expression was carried out using the ReactomeFIPlugin application through cytoscape version 3.6.1. Finally, the study was completed with a survival analysis of both groups. |
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