Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study

Background Processed meat (PM) consumption is an established risk factor for colorectal cancer (CRC). It has been hypothesized that nitrosyl-heme, formed by the addition of nitrites during meat processing, may enhance the carcinogenic effects of PMs. This study aims to investigate the association be...

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Autores: Rizzolo-Brime, Lucía, Lujan-Barroso, Leila, Farran-Codina, Andreu, Bou, Ricard, Nicolas, Genevieve, Huybrechts, Inge, Lasheras, Cristina, Molina Montes, Esther, Colorado-Yohar, Sandra, Gasque, Alba, Dahm, Christina C., Bock, Niels, Olsen, Anja, Tjønneland, Anne, Katzke, Verena, le Cornet, Charlotte, Schulze, Matthias B., Saieva, Calogero, Sieri, Sabina, De Magistris, Maria Santucci, Tumino, Rosario, Macciotta, Alessandra, Wareham, Nick, Weiderpass, Elisabete, Chatziioannou, Chrysovalantou, Vineis, Paolo, Jakszyn, Paula
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12327/5093
Acceso en línea:https://hdl.handle.net/20.500.12327/5093
https://doi.org/10.1186/s12937-025-01266-7
Access Level:acceso abierto
Palabra clave:663/664
id ES_23f2fd2e0587e2fdada48a69153d60f3
oai_identifier_str oai:recercat.cat:20.500.12327/5093
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study
title Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study
spellingShingle Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study
Rizzolo-Brime, Lucía
663/664
title_short Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study
title_full Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study
title_fullStr Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study
title_full_unstemmed Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study
title_sort Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study
dc.creator.none.fl_str_mv Rizzolo-Brime, Lucía
Lujan-Barroso, Leila
Farran-Codina, Andreu
Bou, Ricard
Nicolas, Genevieve
Huybrechts, Inge
Lasheras, Cristina
Molina Montes, Esther
Colorado-Yohar, Sandra
Gasque, Alba
Dahm, Christina C.
Bock, Niels
Olsen, Anja
Tjønneland, Anne
Katzke, Verena
le Cornet, Charlotte
Schulze, Matthias B.
Saieva, Calogero
Sieri, Sabina
De Magistris, Maria Santucci
Tumino, Rosario
Macciotta, Alessandra
Wareham, Nick
Weiderpass, Elisabete
Chatziioannou, Chrysovalantou
Vineis, Paolo
Jakszyn, Paula
author Rizzolo-Brime, Lucía
author_facet Rizzolo-Brime, Lucía
Lujan-Barroso, Leila
Farran-Codina, Andreu
Bou, Ricard
Nicolas, Genevieve
Huybrechts, Inge
Lasheras, Cristina
Molina Montes, Esther
Colorado-Yohar, Sandra
Gasque, Alba
Dahm, Christina C.
Bock, Niels
Olsen, Anja
Tjønneland, Anne
Katzke, Verena
le Cornet, Charlotte
Schulze, Matthias B.
Saieva, Calogero
Sieri, Sabina
De Magistris, Maria Santucci
Tumino, Rosario
Macciotta, Alessandra
Wareham, Nick
Weiderpass, Elisabete
Chatziioannou, Chrysovalantou
Vineis, Paolo
Jakszyn, Paula
author_role author
author2 Lujan-Barroso, Leila
Farran-Codina, Andreu
Bou, Ricard
Nicolas, Genevieve
Huybrechts, Inge
Lasheras, Cristina
Molina Montes, Esther
Colorado-Yohar, Sandra
Gasque, Alba
Dahm, Christina C.
Bock, Niels
Olsen, Anja
Tjønneland, Anne
Katzke, Verena
le Cornet, Charlotte
Schulze, Matthias B.
Saieva, Calogero
Sieri, Sabina
De Magistris, Maria Santucci
Tumino, Rosario
Macciotta, Alessandra
Wareham, Nick
Weiderpass, Elisabete
Chatziioannou, Chrysovalantou
Vineis, Paolo
Jakszyn, Paula
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Indústries Alimentàries
Funcionalitat i Seguretat Alimentària
dc.subject.none.fl_str_mv 663/664
topic 663/664
description Background Processed meat (PM) consumption is an established risk factor for colorectal cancer (CRC). It has been hypothesized that nitrosyl-heme, formed by the addition of nitrites during meat processing, may enhance the carcinogenic effects of PMs. This study aims to investigate the association between nitrosyl-heme intake and CRC risk within the European Prospective Investigation into Cancer and Nutrition(EPIC) study. Methods This prospective study included 367,463 participants(70.3% women) from seven countries from the EPIC-study. Dietary data were collected via baseline questionnaires, and nitrosyl-heme exposure was estimated using biochemical data from 52 Spanish PMs, extrapolated to country-specific items. Sex-specific multivariable-adjusted hazard ratios(HRs) and 95% confidence intervals(CIs) were calculated using Cox proportional hazards models. Results Over a 15-year median follow-up, 5,115 incident CRC cases were identified. Comparing the highest vs. the lowest sex-specific tertile of nitrosyl-heme intake we found no significant association with CRC risk (HRT3vsT1:1.01;95%CI:0.93–1.09). Subgroup analyses by tumor subtype and interactions with lifestyle factors also showed no associations. Conclusions This study offers insights into nitrosyl-heme exposure in European populations but found no link to CRC risk. Further research is needed to understand nitrosyl-heme's role in CRC.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12327/5093
https://doi.org/10.1186/s12937-025-01266-7
url https://hdl.handle.net/20.500.12327/5093
https://doi.org/10.1186/s12937-025-01266-7
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nutrition Journal
ISCIII/Programa Estatal de I+D+I orientada a los retos de la sociedad/PI19-00817/ES/Cancer colorectal y consumo de carnes procesadas. Contenido en nitrosylhemo e implicaciones en la carcinogenesis/
FEDER/ / /EU/ /
ESF/ / /EU/ /
SANCO/ / /EU/ /
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404670988910592
spelling Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort studyRizzolo-Brime, LucíaLujan-Barroso, LeilaFarran-Codina, AndreuBou, RicardNicolas, GenevieveHuybrechts, IngeLasheras, CristinaMolina Montes, EstherColorado-Yohar, SandraGasque, AlbaDahm, Christina C.Bock, NielsOlsen, AnjaTjønneland, AnneKatzke, Verenale Cornet, CharlotteSchulze, Matthias B.Saieva, CalogeroSieri, SabinaDe Magistris, Maria SantucciTumino, RosarioMacciotta, AlessandraWareham, NickWeiderpass, ElisabeteChatziioannou, ChrysovalantouVineis, PaoloJakszyn, Paula663/664Background Processed meat (PM) consumption is an established risk factor for colorectal cancer (CRC). It has been hypothesized that nitrosyl-heme, formed by the addition of nitrites during meat processing, may enhance the carcinogenic effects of PMs. This study aims to investigate the association between nitrosyl-heme intake and CRC risk within the European Prospective Investigation into Cancer and Nutrition(EPIC) study. Methods This prospective study included 367,463 participants(70.3% women) from seven countries from the EPIC-study. Dietary data were collected via baseline questionnaires, and nitrosyl-heme exposure was estimated using biochemical data from 52 Spanish PMs, extrapolated to country-specific items. Sex-specific multivariable-adjusted hazard ratios(HRs) and 95% confidence intervals(CIs) were calculated using Cox proportional hazards models. Results Over a 15-year median follow-up, 5,115 incident CRC cases were identified. Comparing the highest vs. the lowest sex-specific tertile of nitrosyl-heme intake we found no significant association with CRC risk (HRT3vsT1:1.01;95%CI:0.93–1.09). Subgroup analyses by tumor subtype and interactions with lifestyle factors also showed no associations. Conclusions This study offers insights into nitrosyl-heme exposure in European populations but found no link to CRC risk. Further research is needed to understand nitrosyl-heme's role in CRC.This study was supported by grant from the Instituto de Salud Carlos III through the PI19/00817 project (co-funded by the European Regional Development Fund (ERDF), a way to build Europe) and through the PFIS FI20/00006 predoctoral funding (co-funded by the European Social Fund (ESF), investing in your future). The coordination of EPIC-Europe is financially supported by International Agency for Research on Cancer(IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark);Ligue Nationale Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale (MGEN), Institut National de la Santé et de la Recherche Médicale (INSERM), French National Research Agency (ANR, reference ANR-10-COHO-0006), French Ministry for Higher Education (subsidy 2,102,918,823, 2,103,236,497, and 2,103,586,016) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Italian Ministry of Health, Italian Ministry of University and Research (MUR), Compagnia di San Paolo (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, for their contribution and ongoing support to the EPIC Study; the Netherlands Organisation for Health Research and Development (ZonMW), World Cancer Research Fund (WCRF), (The Netherlands); UiT The Arctic University of Norway; Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (C864/A14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (MR/N003284/1, MC-UU_12015/1 and MC_UU_00006/1 to EPIC-Norfolk; MR/Y013662/1 to EPIC-Oxford) (United Kingdom). Previous support has come from “Europe against Cancer” Programme of the European Commission (DG SANCO). We thank CERCA Programme/Generalitat de Catalunya for institutional support.info:eu-repo/semantics/publishedVersionBMCIndústries AlimentàriesFuncionalitat i Seguretat Alimentària2025info:eu-repo/semantics/article12https://hdl.handle.net/20.500.12327/5093https://doi.org/10.1186/s12937-025-01266-7reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNutrition JournalISCIII/Programa Estatal de I+D+I orientada a los retos de la sociedad/PI19-00817/ES/Cancer colorectal y consumo de carnes procesadas. Contenido en nitrosylhemo e implicaciones en la carcinogenesis/FEDER/ / /EU/ /ESF/ / /EU/ /SANCO/ / /EU/ /Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12327/50932026-05-29T05:05:01Z
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