Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years

Vega-Piris, Lorena.; Galindo Carretero, Silvia; Mayordomo, José Luis; Rumayor Zarzuelo, Mercedes Belén; Álvarez Río, Virginia; Gallardo García, Virtudes; García vázquez, Miriam; García Rodríguez, María del Carmen; Basile, Luca; López González-Coviella, Nieves; Barranco Boada, María Isabel; Pérez-Martínez, Olaia; Lameiras Azevedo, Ana; Quiñones Rubio, Carmen; Gimenez Duran, Jaume; Fernández Ibáñez, Ana; García Rivera, María Victoria; Ramos Marín, Violeta; Castrillejo, Daniel; Viloria Raymundo, Luis Javier; Larrauri, Amparo; Monge, Susana

Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years

Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2...

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Detalhes bibliográficos
Autores:	Vega-Piris, Lorena., Galindo Carretero, Silvia, Mayordomo, José Luis, Rumayor Zarzuelo, Mercedes Belén, Álvarez Río, Virginia, Gallardo García, Virtudes, García vázquez, Miriam, García Rodríguez, María del Carmen, Basile, Luca, López González-Coviella, Nieves, Barranco Boada, María Isabel, Pérez-Martínez, Olaia, Lameiras Azevedo, Ana, Quiñones Rubio, Carmen, Gimenez Duran, Jaume, Fernández Ibáñez, Ana, García Rivera, María Victoria, Ramos Marín, Violeta, Castrillejo, Daniel, Viloria Raymundo, Luis Javier, Larrauri, Amparo, Monge, Susana
Formato:	artículo
Fecha de publicación:	2024
País:	España
Recursos:	Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:	Docusalut
Idioma:	inglés
OAI Identifier:	oai:docusalut.com:20.500.13003/21142
Acesso em linha:	https://hdl.handle.net/20.500.13003/21142
Access Level:	acceso abierto
Palavra-chave:	Aged, 80 and over Aged SARS-CoV-2 Spain Hospital Mortality Humans Hospitalization Intensive Care Units Male Severity of Illness Index Influenza, Human Female COVID-19 Respiratory Syncytial Virus, Human Respiratory Syncytial Virus Infections Infecciones por Virus Sincitial Respiratorio Femenino Hospitalización Gripe Humana Unidades de Cuidados Intensivos Masculino Humanos Anciano Mortalidad Hospitalaria Índice de Severidad de la Enfermedad Anciano de 80 o más Años Virus Sincitial Respiratorio Humano España

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spelling	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 yearsVega-Piris, Lorena.Galindo Carretero, SilviaMayordomo, José LuisRumayor Zarzuelo, Mercedes BelénÁlvarez Río, VirginiaGallardo García, VirtudesGarcía vázquez, MiriamGarcía Rodríguez, María del CarmenBasile, LucaLópez González-Coviella, NievesBarranco Boada, María IsabelPérez-Martínez, OlaiaLameiras Azevedo, AnaQuiñones Rubio, CarmenGimenez Duran, JaumeFernández Ibáñez, AnaGarcía Rivera, María VictoriaRamos Marín, VioletaCastrillejo, DanielViloria Raymundo, Luis JavierLarrauri, AmparoMonge, SusanaAged, 80 and overAgedSARS-CoV-2SpainHospital MortalityHumansHospitalizationIntensive Care UnitsMaleSeverity of Illness IndexInfluenza, HumanFemaleCOVID-19Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsAged, 80 and overInfecciones por Virus Sincitial RespiratorioFemeninoCOVID-19HospitalizaciónGripe HumanaUnidades de Cuidados IntensivosMasculinoSARS-CoV-2HumanosAncianoMortalidad HospitalariaÍndice de Severidad de la EnfermedadAnciano de 80 o más AñosVirus Sincitial Respiratorio HumanoEspañaOur aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2. Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR= 0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81 (0.67-0.98)], ICU admission [vs. influenza: 0.93 (0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64 (0.32-1.28); vs. SARS-CoV-2: 0.56 (0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.Elsevier20242024-11-0120242024-11-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/21142reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/211422026-06-22T12:44:07Z
dc.title.none.fl_str_mv	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years
title	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years
spellingShingle	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years Vega-Piris, Lorena. Aged, 80 and over Aged SARS-CoV-2 Spain Hospital Mortality Humans Hospitalization Intensive Care Units Male Severity of Illness Index Influenza, Human Female COVID-19 Respiratory Syncytial Virus, Human Respiratory Syncytial Virus Infections Aged, 80 and over Infecciones por Virus Sincitial Respiratorio Femenino COVID-19 Hospitalización Gripe Humana Unidades de Cuidados Intensivos Masculino SARS-CoV-2 Humanos Anciano Mortalidad Hospitalaria Índice de Severidad de la Enfermedad Anciano de 80 o más Años Virus Sincitial Respiratorio Humano España
title_short	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years
title_full	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years
title_fullStr	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years
title_full_unstemmed	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years
title_sort	Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years
dc.creator.none.fl_str_mv	Vega-Piris, Lorena. Galindo Carretero, Silvia Mayordomo, José Luis Rumayor Zarzuelo, Mercedes Belén Álvarez Río, Virginia Gallardo García, Virtudes García vázquez, Miriam García Rodríguez, María del Carmen Basile, Luca López González-Coviella, Nieves Barranco Boada, María Isabel Pérez-Martínez, Olaia Lameiras Azevedo, Ana Quiñones Rubio, Carmen Gimenez Duran, Jaume Fernández Ibáñez, Ana García Rivera, María Victoria Ramos Marín, Violeta Castrillejo, Daniel Viloria Raymundo, Luis Javier Larrauri, Amparo Monge, Susana
author	Vega-Piris, Lorena.
author_facet	Vega-Piris, Lorena. Galindo Carretero, Silvia Mayordomo, José Luis Rumayor Zarzuelo, Mercedes Belén Álvarez Río, Virginia Gallardo García, Virtudes García vázquez, Miriam García Rodríguez, María del Carmen Basile, Luca López González-Coviella, Nieves Barranco Boada, María Isabel Pérez-Martínez, Olaia Lameiras Azevedo, Ana Quiñones Rubio, Carmen Gimenez Duran, Jaume Fernández Ibáñez, Ana García Rivera, María Victoria Ramos Marín, Violeta Castrillejo, Daniel Viloria Raymundo, Luis Javier Larrauri, Amparo Monge, Susana
author_role	author
author2	Galindo Carretero, Silvia Mayordomo, José Luis Rumayor Zarzuelo, Mercedes Belén Álvarez Río, Virginia Gallardo García, Virtudes García vázquez, Miriam García Rodríguez, María del Carmen Basile, Luca López González-Coviella, Nieves Barranco Boada, María Isabel Pérez-Martínez, Olaia Lameiras Azevedo, Ana Quiñones Rubio, Carmen Gimenez Duran, Jaume Fernández Ibáñez, Ana García Rivera, María Victoria Ramos Marín, Violeta Castrillejo, Daniel Viloria Raymundo, Luis Javier Larrauri, Amparo Monge, Susana
author2_role	author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Aged, 80 and over Aged SARS-CoV-2 Spain Hospital Mortality Humans Hospitalization Intensive Care Units Male Severity of Illness Index Influenza, Human Female COVID-19 Respiratory Syncytial Virus, Human Respiratory Syncytial Virus Infections Aged, 80 and over Infecciones por Virus Sincitial Respiratorio Femenino COVID-19 Hospitalización Gripe Humana Unidades de Cuidados Intensivos Masculino SARS-CoV-2 Humanos Anciano Mortalidad Hospitalaria Índice de Severidad de la Enfermedad Anciano de 80 o más Años Virus Sincitial Respiratorio Humano España
topic	Aged, 80 and over Aged SARS-CoV-2 Spain Hospital Mortality Humans Hospitalization Intensive Care Units Male Severity of Illness Index Influenza, Human Female COVID-19 Respiratory Syncytial Virus, Human Respiratory Syncytial Virus Infections Aged, 80 and over Infecciones por Virus Sincitial Respiratorio Femenino COVID-19 Hospitalización Gripe Humana Unidades de Cuidados Intensivos Masculino SARS-CoV-2 Humanos Anciano Mortalidad Hospitalaria Índice de Severidad de la Enfermedad Anciano de 80 o más Años Virus Sincitial Respiratorio Humano España
description	Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV, compared to influenza or COVID-19. We included hospitalised patients from Severe Acute Respiratory Infection Surveillance in Spain between 2021-2024, aged ≥65 years, laboratory confirmed for RSV, influenza or SARS-CoV-2. Using a binomial regression with logarithmic link, we estimated the relative risk (RR) of pneumonia, ICU admission and in-hospital mortality, in patients with RSV compared to influenza or SARS-CoV-2, adjusting for age, sex, season and comorbidities. We stratified the estimates by vaccination status for influenza or SARS-CoV2. Among patients unvaccinated for influenza or SARS-CoV-2, those with RSV had similar or lower risk of pneumonia [vs. influenza: RR= 0.91 (95% Confidence Interval: 0.72-1.16); vs. SARS-CoV-2: 0.81 (0.67-0.98)], ICU admission [vs. influenza: 0.93 (0.41-2.08); vs. SARS-CoV-2: 1.10 (0.61-1.99)] and mortality [vs. influenza: 0.64 (0.32-1.28); vs. SARS-CoV-2: 0.56 (0.30-1.04)]. Among the vaccinated, results were largely similar except for a higher risk of ICU admission with RSV [vs. influenza: 2.13(1.16-3.89); vs. SARS-CoV-2: 1.83 (1.02-3.28)] CONCLUSIONS: RSV presented similar or lower intrinsic severity than influenza or SARS-CoV2. Among vaccinated patients, RSV was associated to higher ICU-admission, suggesting the potential for preventive RSV vaccination.
publishDate	2024
dc.date.none.fl_str_mv	2024 2024-11-01 2024 2024-11-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.13003/21142
url	https://hdl.handle.net/20.500.13003/21142
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str	Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str	Docusalut
collection	Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years

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