Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry

Vital pulp therapy comprises a group of procedures whose use in the primary dentition is increasingly supported in pediatric dentistry. The clinical management of pediatric patients requires biomaterials that provide precision, ease of handling, and reduced chairside time; in this context, resin-mod...

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Autores: Cabrera Fernández, Alberto, Dominguez-Dominguez, Laura, Pérez Pérez, Antonio, Santos, João Miguel Marques dos, Díaz-Cuenca, Aránzazu, Sánchez Margalet, Víctor, Sequeira, Diana B., Segura Egea, Juan José, Martín González, Jenifer
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:dnet:idus________::5fe960e1f3a579e52d57983c36818b55
Acceso en línea:https://hdl.handle.net/11441/184040
https://doi.org/10.3390/jfb17030147
Access Level:acceso abierto
Palabra clave:Vital pulp therapy
Pediatric dentistry
Resin-modified calcium silicate-based materials
Theracal LC
Indirect pulp capping
Pulpotomy
Meta-analysis
Primary teeth
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spelling Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistryCabrera Fernández, AlbertoDominguez-Dominguez, LauraPérez Pérez, AntonioSantos, João Miguel Marques dosDíaz-Cuenca, AránzazuSánchez Margalet, VíctorSequeira, Diana B.Segura Egea, Juan JoséMartín González, JeniferVital pulp therapyPediatric dentistryResin-modified calcium silicate-based materialsTheracal LCIndirect pulp cappingPulpotomyMeta-analysisPrimary teethVital pulp therapy comprises a group of procedures whose use in the primary dentition is increasingly supported in pediatric dentistry. The clinical management of pediatric patients requires biomaterials that provide precision, ease of handling, and reduced chairside time; in this context, resin-modified calcium silicate-based materials (RM-CSCs) have been introduced as an alternative to conventional calcium silicate formulations. This systematic review and meta-analysis aimed to evaluate the clinical effectiveness of RM-CSCs compared with non-resin calcium silicate-based materials in vital pulp therapy performed in primary teeth. A systematic search was conducted in MEDLINE, Scopus, Embase, and Web of Science in accordance with PRISMA guidelines. Randomized clinical trials were included, the risk of bias was assessed using the RoB 2 tool, and the certainty of evidence was evaluated using the GRADE approach. Of the 605 records initially identified, nine randomized clinical trials were ultimately included, all of which evaluated TheraCal LC as the RM-CSC. Meta-analyses were performed for vital pulp therapy overall and for procedure-specific subanalyses, including indirect pulp capping and pulpotomy. None of the meta-analyses demonstrated statistically significant differences between RM-CSCs and non-resin calcium silicate-based materials in terms of clinical or radiographic success. Therefore, the available evidence supports the use of TheraCal LC as an effective option for indirect pulp capping in primary teeth; however, its use in pulpotomy should be interpreted with caution until further randomized clinical trials become available.MDPIEstomatologíaBioquímica Médica y Biología Molecular e InmunologíaCTS941: Patología Dentaria, Operatoria Dental y EndodonciaCTS151: Bioquímica Medica2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/184040https://doi.org/10.3390/jfb17030147reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésJournal of functional biomaterials, 17 (3), 147. https://www.mdpi.com/2079-4983/17/3/147info:eu-repo/semantics/openAccessoai:dnet:idus________::5fe960e1f3a579e52d57983c36818b552026-06-17T12:51:07Z
dc.title.none.fl_str_mv Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry
title Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry
spellingShingle Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry
Cabrera Fernández, Alberto
Vital pulp therapy
Pediatric dentistry
Resin-modified calcium silicate-based materials
Theracal LC
Indirect pulp capping
Pulpotomy
Meta-analysis
Primary teeth
title_short Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry
title_full Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry
title_fullStr Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry
title_full_unstemmed Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry
title_sort Resin-modified calcium silicate-based materials versus conventional formulations in primary teeth: a systematic review and meta-analysis of clinical and radiographic outcomes of vital pulp therapy procedures in pediatric dentistry
dc.creator.none.fl_str_mv Cabrera Fernández, Alberto
Dominguez-Dominguez, Laura
Pérez Pérez, Antonio
Santos, João Miguel Marques dos
Díaz-Cuenca, Aránzazu
Sánchez Margalet, Víctor
Sequeira, Diana B.
Segura Egea, Juan José
Martín González, Jenifer
author Cabrera Fernández, Alberto
author_facet Cabrera Fernández, Alberto
Dominguez-Dominguez, Laura
Pérez Pérez, Antonio
Santos, João Miguel Marques dos
Díaz-Cuenca, Aránzazu
Sánchez Margalet, Víctor
Sequeira, Diana B.
Segura Egea, Juan José
Martín González, Jenifer
author_role author
author2 Dominguez-Dominguez, Laura
Pérez Pérez, Antonio
Santos, João Miguel Marques dos
Díaz-Cuenca, Aránzazu
Sánchez Margalet, Víctor
Sequeira, Diana B.
Segura Egea, Juan José
Martín González, Jenifer
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Estomatología
Bioquímica Médica y Biología Molecular e Inmunología
CTS941: Patología Dentaria, Operatoria Dental y Endodoncia
CTS151: Bioquímica Medica
dc.subject.none.fl_str_mv Vital pulp therapy
Pediatric dentistry
Resin-modified calcium silicate-based materials
Theracal LC
Indirect pulp capping
Pulpotomy
Meta-analysis
Primary teeth
topic Vital pulp therapy
Pediatric dentistry
Resin-modified calcium silicate-based materials
Theracal LC
Indirect pulp capping
Pulpotomy
Meta-analysis
Primary teeth
description Vital pulp therapy comprises a group of procedures whose use in the primary dentition is increasingly supported in pediatric dentistry. The clinical management of pediatric patients requires biomaterials that provide precision, ease of handling, and reduced chairside time; in this context, resin-modified calcium silicate-based materials (RM-CSCs) have been introduced as an alternative to conventional calcium silicate formulations. This systematic review and meta-analysis aimed to evaluate the clinical effectiveness of RM-CSCs compared with non-resin calcium silicate-based materials in vital pulp therapy performed in primary teeth. A systematic search was conducted in MEDLINE, Scopus, Embase, and Web of Science in accordance with PRISMA guidelines. Randomized clinical trials were included, the risk of bias was assessed using the RoB 2 tool, and the certainty of evidence was evaluated using the GRADE approach. Of the 605 records initially identified, nine randomized clinical trials were ultimately included, all of which evaluated TheraCal LC as the RM-CSC. Meta-analyses were performed for vital pulp therapy overall and for procedure-specific subanalyses, including indirect pulp capping and pulpotomy. None of the meta-analyses demonstrated statistically significant differences between RM-CSCs and non-resin calcium silicate-based materials in terms of clinical or radiographic success. Therefore, the available evidence supports the use of TheraCal LC as an effective option for indirect pulp capping in primary teeth; however, its use in pulpotomy should be interpreted with caution until further randomized clinical trials become available.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/184040
https://doi.org/10.3390/jfb17030147
url https://hdl.handle.net/11441/184040
https://doi.org/10.3390/jfb17030147
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of functional biomaterials, 17 (3), 147.
https://www.mdpi.com/2079-4983/17/3/147
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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