Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study
Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegra vir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Metho...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/177018 |
| Acceso en línea: | https://hdl.handle.net/11441/177018 https://doi.org/10.1186/s12981‑020‑00302‑2 |
| Access Level: | acceso abierto |
| Palabra clave: | HIV infection Highly active antiretroviral therapy Cohort studies Darunavir |
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Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort studyLópez Cortés, Luis FernandoMacías Sánchez, JuanMerchante Gutiérrez, NicolásReal Navarrete, Luis MiguelGonzález-Serna Martín, Manuel AlejandroSuárez-García, InésMoreno, CristinaRuiz-Algueró, MartaPérez-Elías, María JesúsNavarro, MartaDíez Martínez, MarcosHIV infectionHighly active antiretroviral therapyCohort studiesDarunavirBackground: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegra vir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014–2018 and with more than 24 weeks of follow up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with base line VL ≥ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment experienced patients with undetectable viral load as a simplification strategy, allowing once daily, two pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads.Biomed Central LtdMedicinaBioquímica Médica y Biología Molecular e InmunologíaFisiologíaInstituto de Salud Carlos IIIGobierno de EspañaEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/177018https://doi.org/10.1186/s12981‑020‑00302‑2reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésAids research and therapy, 17 (1), 45.RD06/006RD12/0017/0018RD16/0002/0006https://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-020-00302-2info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1770182026-06-17T12:51:07Z |
| dc.title.none.fl_str_mv |
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study |
| title |
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study |
| spellingShingle |
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study López Cortés, Luis Fernando HIV infection Highly active antiretroviral therapy Cohort studies Darunavir |
| title_short |
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study |
| title_full |
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study |
| title_fullStr |
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study |
| title_full_unstemmed |
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study |
| title_sort |
Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice: A multicentre cohort study |
| dc.creator.none.fl_str_mv |
López Cortés, Luis Fernando Macías Sánchez, Juan Merchante Gutiérrez, Nicolás Real Navarrete, Luis Miguel González-Serna Martín, Manuel Alejandro Suárez-García, Inés Moreno, Cristina Ruiz-Algueró, Marta Pérez-Elías, María Jesús Navarro, Marta Díez Martínez, Marcos |
| author |
López Cortés, Luis Fernando |
| author_facet |
López Cortés, Luis Fernando Macías Sánchez, Juan Merchante Gutiérrez, Nicolás Real Navarrete, Luis Miguel González-Serna Martín, Manuel Alejandro Suárez-García, Inés Moreno, Cristina Ruiz-Algueró, Marta Pérez-Elías, María Jesús Navarro, Marta Díez Martínez, Marcos |
| author_role |
author |
| author2 |
Macías Sánchez, Juan Merchante Gutiérrez, Nicolás Real Navarrete, Luis Miguel González-Serna Martín, Manuel Alejandro Suárez-García, Inés Moreno, Cristina Ruiz-Algueró, Marta Pérez-Elías, María Jesús Navarro, Marta Díez Martínez, Marcos |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Medicina Bioquímica Médica y Biología Molecular e Inmunología Fisiología Instituto de Salud Carlos III Gobierno de España European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
| dc.subject.none.fl_str_mv |
HIV infection Highly active antiretroviral therapy Cohort studies Darunavir |
| topic |
HIV infection Highly active antiretroviral therapy Cohort studies Darunavir |
| description |
Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegra vir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014–2018 and with more than 24 weeks of follow up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with base line VL ≥ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment experienced patients with undetectable viral load as a simplification strategy, allowing once daily, two pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11441/177018 https://doi.org/10.1186/s12981‑020‑00302‑2 |
| url |
https://hdl.handle.net/11441/177018 https://doi.org/10.1186/s12981‑020‑00302‑2 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Aids research and therapy, 17 (1), 45. RD06/006 RD12/0017/0018 RD16/0002/0006 https://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-020-00302-2 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
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Biomed Central Ltd |
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reponame:idUS. Depósito de Investigación de la Universidad de Sevilla instname:Universidad de Sevilla (US) |
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Universidad de Sevilla (US) |
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idUS. Depósito de Investigación de la Universidad de Sevilla |
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