Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice

Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Method...

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Autores: Suárez-García, Inés|||0000-0002-7016-716X, Ruiz-Alguero, M.|||0000-0003-0857-0684, Pérez Elías, Mª Jesus|||0000-0001-5700-5257, Navarro Vilasaro, Marta|||0000-0002-3784-4405, Díez Martínez, Marcos, Viciana, Pompeyo|||0000-0001-5606-0166, Pérez-Martínez, Laura|||0000-0002-1384-024X, Górgolas, Miguel, Amador, Concha|||0000-0003-0843-8624, De Zarraga, Miguel Alberto, Jarrín, Inma|||0000-0002-7485-2252, Moreno, Santiago|||0000-0002-2843-1094, Dalmau, David|||0000-0003-1936-478X, Navarro, Maria Luisa, González, Maria Isabel, García, Federico, Gutiérrez, Félix|||0000-0002-9485-6867, Rubio García, Rafael|||0000-0001-8132-4303, Vidal, Francesc|||0000-0002-6692-6186, Berenguer, Juan|||0000-0001-8541-8200, Muñoz Fernández, María Ángeles, Alejos, Belén, Moreno Prieto, Cristina|||0000-0002-3378-3158, Iniesta, Carlos|||0000-0002-0928-2679, Garcia Sousa, Luis Miguel, Sanz Pérez, Nieves, Rava, Marta|||0000-0003-2260-9370, Consuegra Fernández, Irene, Merino de Lucas, Esperanza|||0000-0003-3854-4874, García, Gema, Portilla, Irene, Agea, Iván, Portilla, Joaquín|||0000-0002-3676-9511, Sánchez-Payá, José, Rodríguez, Juan Carlos, Gimeno Gascon, Adelina|||0000-0003-3728-3182, Giner, Livia|||0000-0002-1885-3736, Díez, Marcos, Carreres, Melissa, Reus, Sergio|||0000-0002-3320-9754, Boix, Vicente|||0000-0002-7015-3948, Torrús-Tendero, Diego, López Lirola, Ana, García, Dácil, Díaz-Flores, Felicitas, Gómez, Juan Luis, María del Mar, Alonso, Pelazas, Ricardo, Hernández, Jehovana, Alemán Valls, María Remedios|||0000-0002-4459-1290, Hernández, María Inmaculada, Asensi, Victor|||0000-0003-4211-456X, Valle-Garay, Eulalia|||0000-0002-5998-699X, Rivas Carmenado, María Eugenia, Suárez-Zarracina Secades, Tomas, Pérez Is, Laura, Pulido, Federico|||0000-0002-7414-8812, Bisbal, Otilia|||0000-0003-3746-3378, Hernando, Asunción|||0000-0002-1901-1119, Domínguez-Domínguez, Lourdes|||0000-0001-6018-9026, Rial Crestelo, David|||0000-0001-9951-712X, Bermejo, Laura, Santacreu, Mireia, Iribarren, José Antonio, Arrizabalaga, Julio, Aramburu, María José, Camino, Xabier, Rodríguez-Arrondo, Francisco, Von Wichmann, Miguel Ángel, Pascual Tomé, Lidia, Goenaga, Miguel Ángel, Bustinduy, Mª Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Lizardi, Aitziber, Kortajarena, Xabier, Carmona Oyaga, Maria Pilar, Umerez Igartua, Maitane, Masiá, Mar|||0000-0001-9878-2458, Padilla, Sergio|||0000-0002-8420-7310, Navarro Ruiz, Andrés|||0000-0001-7009-280X, Montolio, Fernando, Robledano, Catalina, Colomé, Joan Gregori, Adsuar, Araceli, Pascual, Rafael, Fernández-González, Marta|||0000-0001-9949-8504, García, Elena, Garcia Gomez, Jose Alberto|||0000-0002-1203-7260, Barber, Xavier|||0000-0003-3079-5855, Muga, Roberto|||0000-0001-6301-431X, Sanvisens, Arantza|||0000-0001-6269-5491, Fuster, Daniel|||0000-0003-1262-5860, López Bernaldo de Quirós, Juan Carlos, Gutiérrez, Isabel, Ramírez, Margarita, Padilla Ortega, Belén, Gijon, Paloma|||0000-0002-5011-1927, Aldámiz-Echevarría, T., Tejerina, Francisco|||0000-0002-4136-3575, Parras, Francisco José, Balsalobre, Pascual, Diez, Cristina, Pérez Latorre, Leire|||0000-0001-9919-3778, Fanciulli, Chiara|||0000-0003-2175-9027, Peraire, Joaquim|||0000-0001-7808-5479, Viladés, Consuelo|||0000-0002-2991-9593, Veloso, Sergio, Vargas Laguna, Montserrat|||0000-0001-7650-0587, Olona, Montserrat|||0000-0001-5303-9361, Rull, Anna|||0000-0002-8907-7754, Rodríguez-Gallego, Esther|||0000-0002-6363-2510, Alba, Verónica|||0000-0002-5925-9573, Castellanos, Alfonso Javier, López-Dupla, Miguel, Montero Alonso, Marta, López Aldeguer, José, Blanes Juliá, Marino, Tasias Pitarch, María, Castro Hernández, Iván, Calabuig Muñoz, Eva, Cuéllar Tovar, Sandra, Salavert, Miguel|||0000-0002-8571-2124, Fernández Navarro, Juan, González-García, Juan|||0000-0002-3652-002X, Arnalich Fernandez, Francisco|||0000-0003-2943-0373, Arribas, Jose|||0000-0002-7410-9450, Bernardino de la Serna, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz Pinto, Pedro|||0000-0002-9840-6628, Hontañón Antoñana, Víctor|||0000-0003-3070-2647, García-Bujalance, Sílvia, García López-Hortelano, Milagros, González-Baeza, Alicia, Martín Carbonero, Luz|||0000-0001-8102-4079, Mayoral, Mario, Mellado Peña, Maria José|||0000-0003-2251-9666, Micán, Rafael|||0000-0002-6626-4266, Montejano Sanchez, Rocio|||0000-0002-3446-0545, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Sainz, Talia|||0000-0002-5301-0945, Sendagorta, Elena, Stella Alcáriz, Natalia, Valencia, Eulalia|||0000-0001-6902-0120, Blanco, José Ramón|||0000-0002-4268-0150, Oteo, José A.|||0000-0001-7080-6542, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria|||0000-0003-0693-2266, Jaén, Angels, Sanmartí Vilamala, Montserrat|||0000-0002-0432-7073, Cairó, Mireia|||0000-0003-2386-2765, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, M.|||0000-0003-1463-6344, Alonso, Noemí, Rivero Marcotegui, María, Repáraz, Jesús, Gracia Ruiz de Alda, María, De León Cano, María Teresa, Pierola Ruiz de Galarreta, Beatriz, Amengual Guedan, Maria Jose|||0000-0002-5385-3061, Navarro Rubio, Gemma|||0000-0002-7195-9046, Cervantes Garcia, Manuel|||0000-0001-6073-1110, Calzado, Sonia|||0000-0002-2975-6448, de los Santos Gil, Ignacio|||0000-0001-7073-5211, Sanz Sanz, Jesús, Salas Aparicio, Ana, Sarriá Cepeda, Cristina, García-Fraile Fraile, Lucio|||0000-0002-2512-6107, Martín Gayo, Enrique|||0000-0002-2619-6086, Casado Osorio, José Luis, Dronda, Fernando|||0000-0002-0443-5816, Moreno Zamora, Ana, Gutiérrez, Carolina, Madrid, Nadia, del Campo, Santos|||0000-0003-2234-5432, Serrano-Villar, Sergio|||0000-0002-5447-3554, Vivancos-Gallego, María J.|||0000-0002-9373-6011, Martínez Sanz, Javier|||0000-0003-2020-3908, Anxa Urroz, Usua, Velasco, Tamara, Bernal, Enrique|||0000-0002-4041-0579, Cano Sánchez, Alfredo, Alcaraz García, Antonia, Bravo Urbieta, Joaquín|||0000-0003-2079-0305, Muñoz Pérez, María José, Alcaraz, Mª José|||0000-0002-1057-0299, Villalba, Maria del Carmen, Hernández Quero, José, Muñoz Medina, Leopoldo|||0000-0001-8995-8271, Álvarez, Marta, Chueca, Natalia|||0000-0002-3420-3290, Vinuesa, David|||0000-0002-5663-8447, Martinez-Montes, Clara, Guerrero Beltran, Carlos, de Salazar, Adolfo|||0000-0002-4318-858X, Fuentes López, Ana, Raposo Utrilla, Montserrat, Del Romero, Jorge, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar|||0000-0002-3841-7747, Ballesteros, Juan, Ayerdi, Oskar|||0000-0002-9441-8031, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María|||0000-0001-6290-3457, Leyes, María, Ribas, Maria Àngels, Campins, Antoni A., Vidal, Carmen|||0000-0003-2768-2710, Fanjul, Francisco, Murillas, Javier|||0000-0003-2169-7110, Homar, Francisco|||0000-0003-0116-3277, Santos, Jesús, Gómez Ayerbe, Cristina, Viciana, Isabel, Palacios, Rosario, Pérez López, Carmen, González Domenec, Carmen María, Espinosa, Nuria|||0000-0003-2249-2352, López Cortés, Luis Fernando|||0000-0002-3804-3458, Podzamczer, Daniel|||0000-0001-7090-3561, Imaz, Arkaitz|||0000-0001-8411-1952, Tiraboschi, Juan Manuel|||0000-0002-0073-873X, Silva, Ana, Saumoy, Maria|||0000-0002-0047-1991, Prieto, Paula Florencia|||0000-0003-1978-758X, Ribera, Esteban|||0000-0002-3752-8808, Curran, Adrian|||0000-0002-1263-0814, Olalla Sierra, Julián, Pérez Stachowski, Javier|||0000-0002-5189-1953, del Arco Jiménez, Alfonso|||0000-0002-5432-4591, De La Torre, Javier, Prada, José Luis, García de Lomas Guerrero, José María|||0000-0001-8160-8488, Martínez, Onofre Juan, Vera, Francisco Jesús, Martínez, Lorena, García, Josefina, Alcaraz, Begoña, Jimeno, Amaya, Castro Iglesias, Angeles|||0000-0002-8418-9749, Pernas Souto, Berta|||0000-0002-2061-3096, Mena de Cea, Álvaro, Muñoz, Josefa, Zuriñe Zubero, Miren, Baraia-Etxaburu, Josu Mirena, Ibarra Ugarte, Sofía, Ferrero Beneitez, Oscar Luis, López de Munain, Josefina, Cámara López, Maria Mar, De La Peña, Mireia, López, Miriam, López Azkarreta, Iñigo, Galera, Carlos, Albendin, Helena, Pérez, Aurora, Iborra, Asunción, Moreno, Antonio, Merlos, María Angustias, Vidal, Asunción, Meca, Marisa, Pasquau, Francisco, Ena, Javier|||0000-0002-1181-7396, Benito, Concha, Fenoll, Vicenta, Gil Anguita, Concepción, Algado Rabasa, Jose Tomás, Malmierca Corral, Eduardo|||0000-0002-4071-7247, González-Ruano, Patricia|||0000-0003-0395-7740, Martín Rodrigo, Dolores, Ruiz Seco, María Pilar, Mohamed-Balghata, Mohamed Omar, Gómez Vidal, María Amparo, Estrada, Vicente|||0000-0002-7795-5986, Téllez Molina, María Jesús, Vergas García, Jorge, Pérez-Somarriba Moreno, Juncal|||0000-0002-9623-5781, Cabello-Ubeda, Alfonso|||0000-0001-8429-8358, Álvarez, Beatriz, Prieto, Laura, Sanz Moreno, José, Arranz Caso, Alberto, Hernández Gutiérrez, Cristina, Novella Mena, María, Galindo Puerto, María José, Vilalta, Ramón Fernando, Ferrer Ribera, Ana, Rivero Román, Antonio|||0000-0002-8643-4250, Rivero-Juarez, Antonio|||0000-0002-5813-6889, López López, Pedro|||0000-0001-5740-6675, Machuca Sánchez, Isabel|||0000-0003-3343-0085, Frias Casas, Mario, Camacho Espejo, Angela, Cervero Jiménez, Miguel|||0000-0001-9387-7917, Torres Perea, Rafael, Pineda, Juan A.|||0000-0002-3751-0296, Rincón Mayo, Pilar, Macías, Juan|||0000-0002-4778-790X, Merchante, Nicolás|||0000-0003-1120-8942, Real, Luis M.|||0000-0003-4932-7429, Corma Gómez, Anaïs|||0000-0002-1078-0237, Fernández Fuertes, Marta, Gonzalez-Serna, Alejandro|||0000-0002-0239-8417, Poveda, Eva|||0000-0003-4835-9875, Pérez González, Alexandre|||0000-0003-4836-6768, Crespo Casal, Manuel|||0000-0001-9016-0515, Morano, Luis, Miralles, Celia, Ocampo Hermida, Antonio|||0000-0002-3176-9758, Pousada, Guillermo|||0000-0002-2466-8094
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:293966
Acceso en línea:https://ddd.uab.cat/record/293966
https://dx.doi.org/urn:doi:10.1186/s12981-020-00302-2
Access Level:acceso abierto
Palabra clave:Cohort studies
Darunavir
HIV infection
Highly active antiretroviral therapy
Descripción
Sumario:Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014-2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL ≥ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads.