New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents
The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2011 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/18732 |
| Acceso en línea: | https://hdl.handle.net/10171/18732 |
| Access Level: | acceso abierto |
| Palabra clave: | Anti-Tuberculosis agents Quinoxaline 1,4-di-N-oxide derivatives Isoniazid Microwave assisted synthesis Druglikeness |
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New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agentsTorres, E. (Enrique)|||/items/63f6c247-849f-4192-9a16-b86398ba3fc5Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfaAncizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223dAldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45Anti-Tuberculosis agentsQuinoxaline 1,4-di-N-oxide derivativesIsoniazidMicrowave assisted synthesisDruglikenessThe increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4-di-N-oxide derivatives containing isoniazid was synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain. Moreover, various drug-like properties of new compounds were predicted. Taking into account the biological results and the promising drug-likeness profile of these compounds, make them valid leads for further experimental research.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20112011-07-0420112011-01-0120112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/18732reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/187322026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title |
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| spellingShingle |
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents Torres, E. (Enrique)|||/items/63f6c247-849f-4192-9a16-b86398ba3fc5 Anti-Tuberculosis agents Quinoxaline 1,4-di-N-oxide derivatives Isoniazid Microwave assisted synthesis Druglikeness |
| title_short |
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_full |
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_fullStr |
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_full_unstemmed |
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| title_sort |
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterieum tuberculosis agents |
| dc.creator.none.fl_str_mv |
Torres, E. (Enrique)|||/items/63f6c247-849f-4192-9a16-b86398ba3fc5 Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 |
| author |
Torres, E. (Enrique)|||/items/63f6c247-849f-4192-9a16-b86398ba3fc5 |
| author_facet |
Torres, E. (Enrique)|||/items/63f6c247-849f-4192-9a16-b86398ba3fc5 Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 |
| author_role |
author |
| author2 |
Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Anti-Tuberculosis agents Quinoxaline 1,4-di-N-oxide derivatives Isoniazid Microwave assisted synthesis Druglikeness |
| topic |
Anti-Tuberculosis agents Quinoxaline 1,4-di-N-oxide derivatives Isoniazid Microwave assisted synthesis Druglikeness |
| description |
The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4-di-N-oxide derivatives containing isoniazid was synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain. Moreover, various drug-like properties of new compounds were predicted. Taking into account the biological results and the promising drug-likeness profile of these compounds, make them valid leads for further experimental research. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011 2011-07-04 2011 2011-01-01 2011 2011-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/18732 |
| url |
https://hdl.handle.net/10171/18732 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15,301603 |