Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis

Schizophrenia (SZ) is a severe mental health condition involving gene-environment interactions, with obstetric complications (OCs) conferring an elevated risk for the disease. Current research suggests that OCs may exacerbate SZ symptoms. This study conducted a systematic review and meta-analysis to...

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Detalles Bibliográficos
Autores: Forte, Maria Florencia, Oliva, Vincenzo, De Prisco, Michele, Garriga, Marina, Bitanihirwe, Byron, Alameda, Luis, González-Segura, Àlex, Vieta, Eduard, Baeza, Inmaculada, Parellada, Eduard, Penadés, Rafael, Ramos-Quiroga, J. Antoni, Amoretti, Silvia, Mezquida, Gisela, Garcia-Rizo, Clemente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/387182
Acceso en línea:http://hdl.handle.net/10261/387182
https://api.elsevier.com/content/abstract/scopus_id/85205895605
Access Level:acceso abierto
Palabra clave:Depressive symptoms
Developmental origins of health and disease
Negative symptoms
Obstetric complications
Positive symptoms
Psychopathology
Psychosis
Schizophrenia
Descripción
Sumario:Schizophrenia (SZ) is a severe mental health condition involving gene-environment interactions, with obstetric complications (OCs) conferring an elevated risk for the disease. Current research suggests that OCs may exacerbate SZ symptoms. This study conducted a systematic review and meta-analysis to comprehensively evaluate differences in psychopathology between individuals with and without exposure to OCs in relation to SZ and related disorders. We systematically searched PubMed, PsycINFO, and SCOPUS to identify eligible studies. A total of 4091 records were retrieved through systematic and citation searches. 14 studies were included in the review, and 12 met the criteria for meta-analysis, involving 2992 patients. The analysis revealed that SZ patients who had been exposed to OCs exhibited significantly higher levels of positive symptoms (SMD=0.10, 95 %CI=0.01,0.20; p=0.03), general psychopathology (SMD=0.37, 95 %CI=0.22,0.52; p<0.001), total clinical symptomatology (SMD=0.44, 95 %CI=0.24,0.64; p<0.001) and depressive symptoms (SMD=0.47, 95 %CI=0.09,0.84; p=0.01). No significant differences were found in negative symptomatology and functioning. Our results suggest that OCs are not only associated with an increased risk of developing psychosis but with more severe symptomatology.

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