A Bayesian stochastic SIRS model with a vaccination strategy for the analysis of respiratory syncytial virus

Our objective in this paper is to model the dynamics of respiratory syncytial virus in the region of Valencia (Spain) and analyse the effect of vaccination strategies from a health-economic point of view. Compartmental mathematical models based on differential equations are commonly used in epidemio...

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Bibliographic Details
Authors: Jornet-Sanz, Marc, Corberán-Vallet, Ana, Santonja Gómez, Francisco José, Villanueva Micó, Rafael
Format: article
Publication Date:2017
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:176150
Online Access:https://ddd.uab.cat/record/176150
https://dx.doi.org/urn:doi:10.2436/20.8080.02.56
Access Level:Open access
Keyword:Infectious diseases
Respiratory Syncytial Virus (RSV)
Discrete-time epidemic model
Stochastic compartmental model
Bayesian analysis
Intervention strategies
Description
Summary:Our objective in this paper is to model the dynamics of respiratory syncytial virus in the region of Valencia (Spain) and analyse the effect of vaccination strategies from a health-economic point of view. Compartmental mathematical models based on differential equations are commonly used in epidemiology to both understand the underlying mechanisms that influence disease transmission and analyse the impact of vaccination programs. However, a recently proposed Bayesian stochastic susceptible-infected-recovered-susceptible model in discrete-time provided an improved and more natural description of disease dynamics. In this work, we propose an extension of that stochastic model that allows us to simulate and assess the effect of a vaccination strategy that consists on vaccinating a proportion of newborns.