Asymmetric Synthesis of -Disubstituted Allylic Amines via Pd- Catalyzed Allylic Substitution
The first asymmetric synthesis of important - disubstituted N-alkyl allyl amine scaffolds via allylic substitution is reported. This approach is based on palladium catalysis and features ample scope in both allylic precursor and amine reagent, and high asymmetric induction with the enantiomeric r...
| Autores: | , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/356062 |
| Acesso em linha: | http://hdl.handle.net/2072/356062 https://doi.org/10.1002/anie.201705825 |
| Access Level: | acceso abierto |
| Palavra-chave: | 54 |
| Resumo: | The first asymmetric synthesis of important - disubstituted N-alkyl allyl amine scaffolds via allylic substitution is reported. This approach is based on palladium catalysis and features ample scope in both allylic precursor and amine reagent, and high asymmetric induction with the enantiomeric ratio (er) up to 98.5:1.5. The use of less reactive anilines is also feasible providing enantioenriched -disubstituted N-aryl allylic amines. |
|---|