Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).

The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk...

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Autores: Genescà E, Morgades M, González-Gil C, Fuster-Tormo F, Haferlach C, Meggendorfer M, Montesinos P, Barba P, Gil C, Coll R, Moreno MJ, Martínez-Carballeira D, García-Cadenas I, Vives S, Ribera J, González-Campos J, Díaz-Beya M, Mercadal S, Artola MT, Cladera A, Tormo M, Bermúdez A, Vall-Llovera F, Martínez-Sánchez P, Amigo ML, Monsalvo S, Novo A, Cervera M, García-Guiñon A, Ciudad J, Cervera J, Hernández-Rivas JM, Granada I, Haferlach T, Orfao A, Solé F, Ribera JM
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:INCLIVA
Repositório:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15797
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/15797
Access Level:Acceso aberto
Palavra-chave:Adult T-ALL
Cytogenetics
NGS
Prognosis
Therapy
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spelling Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).Genescà EMorgades MGonzález-Gil CFuster-Tormo FHaferlach CMeggendorfer MMontesinos PBarba PGil CColl RMoreno MJMartínez-Carballeira DGarcía-Cadenas IVives SRibera JGonzález-Campos JDíaz-Beya MMercadal SArtola MTCladera ATormo MBermúdez AVall-Llovera FMartínez-Sánchez PAmigo MLMonsalvo SNovo ACervera MGarcía-Guiñon ACiudad JCervera JHernández-Rivas JMGranada IHaferlach TOrfao ASolé FRibera JMAdult T-ALLCytogeneticsNGSPrognosisTherapyThe potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. Complex karyotype defined by the presence of =3 cytogenetic alterations identified T-ALL patients with poor prognosis in this study. Karyotypes with =3 abnormalities accounted for 16 % (22/139) of all evaluable karyotypes, corresponding to the largest poor prognosis cytogenetic subgroup of T-ALL identified so far. Patients carrying karyotypes with =3 cytogenetic alterations showed a significantly inferior response to therapy, and a poor outcome in terms of event-free survival (EFS), overall survival (OS) and cumulative incidence of relapse (CIR), independently of other baseline characteristics and the end-induction minimal residual disease (MRD) level. Additional molecular analyses of patients carrying =3 cytogenetic alterations showed a unique molecular profile that could contribute to understand the underlying molecular mechanisms of resistance and to evaluate novel targeted therapies (e.g. IL7R directed) with potential impact on outcome of adult T-ALL patients.PERGAMON-ELSEVIER SCIENCE LTD2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15797LEUKEMIA RESEARCHISSN: 01452126ISSNe: 18735835reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p157972026-06-07T16:35:31Z
dc.title.none.fl_str_mv Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
title Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
spellingShingle Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
Genescà E
Adult T-ALL
Cytogenetics
NGS
Prognosis
Therapy
title_short Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
title_full Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
title_fullStr Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
title_full_unstemmed Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
title_sort Adverse prognostic impact of complex karyotype (=3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL).
dc.creator.none.fl_str_mv Genescà E
Morgades M
González-Gil C
Fuster-Tormo F
Haferlach C
Meggendorfer M
Montesinos P
Barba P
Gil C
Coll R
Moreno MJ
Martínez-Carballeira D
García-Cadenas I
Vives S
Ribera J
González-Campos J
Díaz-Beya M
Mercadal S
Artola MT
Cladera A
Tormo M
Bermúdez A
Vall-Llovera F
Martínez-Sánchez P
Amigo ML
Monsalvo S
Novo A
Cervera M
García-Guiñon A
Ciudad J
Cervera J
Hernández-Rivas JM
Granada I
Haferlach T
Orfao A
Solé F
Ribera JM
author Genescà E
author_facet Genescà E
Morgades M
González-Gil C
Fuster-Tormo F
Haferlach C
Meggendorfer M
Montesinos P
Barba P
Gil C
Coll R
Moreno MJ
Martínez-Carballeira D
García-Cadenas I
Vives S
Ribera J
González-Campos J
Díaz-Beya M
Mercadal S
Artola MT
Cladera A
Tormo M
Bermúdez A
Vall-Llovera F
Martínez-Sánchez P
Amigo ML
Monsalvo S
Novo A
Cervera M
García-Guiñon A
Ciudad J
Cervera J
Hernández-Rivas JM
Granada I
Haferlach T
Orfao A
Solé F
Ribera JM
author_role author
author2 Morgades M
González-Gil C
Fuster-Tormo F
Haferlach C
Meggendorfer M
Montesinos P
Barba P
Gil C
Coll R
Moreno MJ
Martínez-Carballeira D
García-Cadenas I
Vives S
Ribera J
González-Campos J
Díaz-Beya M
Mercadal S
Artola MT
Cladera A
Tormo M
Bermúdez A
Vall-Llovera F
Martínez-Sánchez P
Amigo ML
Monsalvo S
Novo A
Cervera M
García-Guiñon A
Ciudad J
Cervera J
Hernández-Rivas JM
Granada I
Haferlach T
Orfao A
Solé F
Ribera JM
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Adult T-ALL
Cytogenetics
NGS
Prognosis
Therapy
topic Adult T-ALL
Cytogenetics
NGS
Prognosis
Therapy
description The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. Complex karyotype defined by the presence of =3 cytogenetic alterations identified T-ALL patients with poor prognosis in this study. Karyotypes with =3 abnormalities accounted for 16 % (22/139) of all evaluable karyotypes, corresponding to the largest poor prognosis cytogenetic subgroup of T-ALL identified so far. Patients carrying karyotypes with =3 cytogenetic alterations showed a significantly inferior response to therapy, and a poor outcome in terms of event-free survival (EFS), overall survival (OS) and cumulative incidence of relapse (CIR), independently of other baseline characteristics and the end-induction minimal residual disease (MRD) level. Additional molecular analyses of patients carrying =3 cytogenetic alterations showed a unique molecular profile that could contribute to understand the underlying molecular mechanisms of resistance and to evaluate novel targeted therapies (e.g. IL7R directed) with potential impact on outcome of adult T-ALL patients.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/15797
url https://incliva.portalinvestigacion.com/publicaciones/15797
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
dc.source.none.fl_str_mv LEUKEMIA RESEARCH
ISSN: 01452126
ISSNe: 18735835
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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