Supramolecular strategies for intracellular delivery and design of new thermoresponsive materials

In this Ph.D. dissertation, we have applied supramolecular strategies to promote intracellular delivery of diverse molecules and design potential thermoresponsive systems. Host-guest chemistry has been exploited to encapsulate and deliver different anionic probes such as pyranine, as well as anionic...

ver descrição completa

Detalhes bibliográficos
Autor: Fernández Caro, Héctor
Formato: tesis doctoral
Fecha de publicación:2020
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/24499
Acesso em linha:http://hdl.handle.net/10347/24499
Access Level:acceso abierto
Palavra-chave:Materias::Investigación::23 Química::2302 Bioquímica::230224 Péptidos
Descrição
Resumo:In this Ph.D. dissertation, we have applied supramolecular strategies to promote intracellular delivery of diverse molecules and design potential thermoresponsive systems. Host-guest chemistry has been exploited to encapsulate and deliver different anionic probes such as pyranine, as well as anionic peptides with low self-delivery efficiency. Finally, we have designed potential thermoresponsive supramolecular materials based on self-assembling cyclic peptide nanotubes (SCPNs).