Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens

Martínez, Isidoro|||0000-0002-9949-9264; Oliveros, Juan C.; Cuesta, Isabel; de la Barrera, Jorge; Ausina, Vicente|||0000-0002-1798-9869; Casals, Cristina; de Lorenzo, Alba; García, Ernesto; García Fojeda, Belén; Garmendia, Junkal; González Nicolau, Mar; Lacoma, Alicia|||0000-0002-2049-3872; Menéndez, Margarita; Moranta, D.|||0000-0001-9528-4920; Nieto, Amelia; Ortín, Juan; Pérez González, Alicia; Prat i Aymerich, Cristina|||0000-0001-6974-9165; Ramos Sevillano, Elisa; Regueiro, Verónica; Rodriguez Frandsen, Ariel; Solís, Dolores; Yuste, José|||0000-0001-7996-0837; Bengoechea, José A.; Melero, José A.

Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens

Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify ne...

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Autores:	Martínez, Isidoro\|\|\|0000-0002-9949-9264, Oliveros, Juan C., Cuesta, Isabel, de la Barrera, Jorge, Ausina, Vicente\|\|\|0000-0002-1798-9869, Casals, Cristina, de Lorenzo, Alba, García, Ernesto, García Fojeda, Belén, Garmendia, Junkal, González Nicolau, Mar, Lacoma, Alicia\|\|\|0000-0002-2049-3872, Menéndez, Margarita, Moranta, D.\|\|\|0000-0001-9528-4920, Nieto, Amelia, Ortín, Juan, Pérez González, Alicia, Prat i Aymerich, Cristina\|\|\|0000-0001-6974-9165, Ramos Sevillano, Elisa, Regueiro, Verónica, Rodriguez Frandsen, Ariel, Solís, Dolores, Yuste, José\|\|\|0000-0001-7996-0837, Bengoechea, José A., Melero, José A.
Tipo de recurso:	artículo
Fecha de publicación:	2017
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:196399
Acceso en línea:	https://ddd.uab.cat/record/196399 https://dx.doi.org/urn:doi:10.3389/fmicb.2017.00276
Access Level:	acceso abierto
Palabra clave:	Respiratory pathogens Host response Core of up-regulated genes Bacterial infections Viral infections

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repository_id_str
spelling	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogensMartínez, Isidoro\|\|\|0000-0002-9949-9264Oliveros, Juan C.Cuesta, Isabelde la Barrera, JorgeAusina, Vicente\|\|\|0000-0002-1798-9869Casals, Cristinade Lorenzo, AlbaGarcía, ErnestoGarcía Fojeda, BelénGarmendia, JunkalGonzález Nicolau, MarLacoma, Alicia\|\|\|0000-0002-2049-3872Menéndez, MargaritaMoranta, D.\|\|\|0000-0001-9528-4920Nieto, AmeliaOrtín, JuanPérez González, AliciaPrat i Aymerich, Cristina\|\|\|0000-0001-6974-9165Ramos Sevillano, ElisaRegueiro, VerónicaRodriguez Frandsen, ArielSolís, DoloresYuste, José\|\|\|0000-0001-7996-0837Bengoechea, José A.Melero, José A.Respiratory pathogensHost responseCore of up-regulated genesBacterial infectionsViral infectionsLower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.Universitat Autònoma de Barcelona 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/196399https://dx.doi.org/urn:doi:10.3389/fmicb.2017.00276reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 PITN-GA-2012-317297Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI15CIII/00024Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-67033-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2014-57797-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-65307-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2012-39444-C01/02Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2012-39841Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-66520-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2015-70052-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 BES-2013-065355open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1963992026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
title	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
spellingShingle	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens Martínez, Isidoro\|\|\|0000-0002-9949-9264 Respiratory pathogens Host response Core of up-regulated genes Bacterial infections Viral infections
title_short	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
title_full	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
title_fullStr	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
title_full_unstemmed	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
title_sort	Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
dc.creator.none.fl_str_mv	Martínez, Isidoro\|\|\|0000-0002-9949-9264 Oliveros, Juan C. Cuesta, Isabel de la Barrera, Jorge Ausina, Vicente\|\|\|0000-0002-1798-9869 Casals, Cristina de Lorenzo, Alba García, Ernesto García Fojeda, Belén Garmendia, Junkal González Nicolau, Mar Lacoma, Alicia\|\|\|0000-0002-2049-3872 Menéndez, Margarita Moranta, D.\|\|\|0000-0001-9528-4920 Nieto, Amelia Ortín, Juan Pérez González, Alicia Prat i Aymerich, Cristina\|\|\|0000-0001-6974-9165 Ramos Sevillano, Elisa Regueiro, Verónica Rodriguez Frandsen, Ariel Solís, Dolores Yuste, José\|\|\|0000-0001-7996-0837 Bengoechea, José A. Melero, José A.
author	Martínez, Isidoro\|\|\|0000-0002-9949-9264
author_facet	Martínez, Isidoro\|\|\|0000-0002-9949-9264 Oliveros, Juan C. Cuesta, Isabel de la Barrera, Jorge Ausina, Vicente\|\|\|0000-0002-1798-9869 Casals, Cristina de Lorenzo, Alba García, Ernesto García Fojeda, Belén Garmendia, Junkal González Nicolau, Mar Lacoma, Alicia\|\|\|0000-0002-2049-3872 Menéndez, Margarita Moranta, D.\|\|\|0000-0001-9528-4920 Nieto, Amelia Ortín, Juan Pérez González, Alicia Prat i Aymerich, Cristina\|\|\|0000-0001-6974-9165 Ramos Sevillano, Elisa Regueiro, Verónica Rodriguez Frandsen, Ariel Solís, Dolores Yuste, José\|\|\|0000-0001-7996-0837 Bengoechea, José A. Melero, José A.
author_role	author
author2	Oliveros, Juan C. Cuesta, Isabel de la Barrera, Jorge Ausina, Vicente\|\|\|0000-0002-1798-9869 Casals, Cristina de Lorenzo, Alba García, Ernesto García Fojeda, Belén Garmendia, Junkal González Nicolau, Mar Lacoma, Alicia\|\|\|0000-0002-2049-3872 Menéndez, Margarita Moranta, D.\|\|\|0000-0001-9528-4920 Nieto, Amelia Ortín, Juan Pérez González, Alicia Prat i Aymerich, Cristina\|\|\|0000-0001-6974-9165 Ramos Sevillano, Elisa Regueiro, Verónica Rodriguez Frandsen, Ariel Solís, Dolores Yuste, José\|\|\|0000-0001-7996-0837 Bengoechea, José A. Melero, José A.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Respiratory pathogens Host response Core of up-regulated genes Bacterial infections Viral infections
topic	Respiratory pathogens Host response Core of up-regulated genes Bacterial infections Viral infections
description	Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
publishDate	2017
dc.date.none.fl_str_mv	2 2017-01-01 2017 2017-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/196399 https://dx.doi.org/urn:doi:10.3389/fmicb.2017.00276
url	https://ddd.uab.cat/record/196399 https://dx.doi.org/urn:doi:10.3389/fmicb.2017.00276
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	European Commission https://doi.org/10.13039/501100000780 PITN-GA-2012-317297 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI15CIII/00024 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-67033-R Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2014-57797-R Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-65307-R Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2012-39444-C01/02 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2012-39841 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-66520-R Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2015-70052-R Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BES-2013-065355
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens

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