Bis-Bingel-functionalization of Lu3N@Ih-C80 using a supramolecular mask to enhance the TNT-EMF reactivity

Exoedral functionalization of endohedral metallofullerenes (EMFs) is crucial to use these interesting molecules as novel materials for applications in fields such as biomedicine and organic solar cell device design. In the case of trimetallic nitride template EMFs (TNT-EMFs), many functionalization...

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Detalles Bibliográficos
Autores: Iannace, Valentina, Sabrià, Clara, A. Stasyuk, Olga, Solà, Miquel, Parella, Teodor, Fernández, Sergio, Gándara, Felipe, Imaz, Inhar, Maspoch, Daniel, Zu, Sheng, Zhang, Jianyuan, Feixas, Ferrran, Ribas, Xavi
Tipo de recurso: conjunto de datos
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::f6b7e540b4d5a658b41b7b63c45eb9a6
Acceso en línea:http://hdl.handle.net/10261/430249
Access Level:acceso abierto
Palabra clave:MD simulations
Funcionalization of EMFs
Lu3N@Ih-C80
Descripción
Sumario:Exoedral functionalization of endohedral metallofullerenes (EMFs) is crucial to use these interesting molecules as novel materials for applications in fields such as biomedicine and organic solar cell device design. In the case of trimetallic nitride template EMFs (TNT-EMFs), many functionalization methods that work on empty fullerenes are inaccessible or less effective due to the presence of the inner cluster, which increases the electron density on the surface of the carbon cage, making them less reactive. Moreover, it has been demonstrated that the inner cluster governs the reactivity and the regioselectivity of bare TNT-EMFs. The Supramolecular Mask Strategy (SMS) has shown promising results in the functionalization of C60 and C70 and is, for the first time in this work, applied to endohedral fullerenes to obtain mono- and bis-functionalization of Lu3N@Ih-C80. The stabilization of Lu3N@Ih-C80 provided by the supramolecular host is crucial to obtaining functionalization under milder conditions and with shorter reaction times. By means of MD simulations and DFT calculations, the most favorable and stable bis-adducts have been identified, considering the alignment between the geometry imposed by the inner cluster and that permitted by the tetragonal prismatic nanocapsule host.