Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder

Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies....

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Autores: Iranzo, Alex, Mammana, Angela, Muñoz Lopetegi, Amaia, Dellavalle, Sofia, Mayà Casalprim, Gerard, Rossi, Marcello, Serradell, Mónica, Baiardi, Simone, Arqueros, Aurora, Quadalti, Corinne, Perissinotti, Andrés, Ruggeri, Edoardo, Santamaria Cano, Joan, Gaig Ventura, Carles, Parchi, Piero
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/220233
Acesso em linha:https://hdl.handle.net/2445/220233
Access Level:acceso abierto
Palavra-chave:Trastorns del son
Demència amb cossos de Lewy
Malaltia de Parkinson
Sleep disorders
Lewy body dementia
Parkinson's disease
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spelling Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior DisorderIranzo, AlexMammana, AngelaMuñoz Lopetegi, AmaiaDellavalle, SofiaMayà Casalprim, GerardRossi, MarcelloSerradell, MónicaBaiardi, SimoneArqueros, AuroraQuadalti, CorinnePerissinotti, AndrésRuggeri, EdoardoSantamaria Cano, JoanGaig Ventura, CarlesParchi, PieroTrastorns del sonDemència amb cossos de LewyMalaltia de ParkinsonSleep disordersLewy body dementiaParkinson's diseaseReal-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies. We aimed to compare the ability of RT-QuIC to identify AS in the skin and CSF of patients with IRBD.Lippincott, Williams & Wilkins. Wolters Kluwer Health2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/220233Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1212/WNL.0000000000207147Neurology, 2023, vol. 100, num.18, p. E1944-E1954https://doi.org/10.1212/WNL.0000000000207147(c) American Academy of Neurology, 2023info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2202332026-05-27T06:46:51Z
dc.title.none.fl_str_mv Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
title Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
spellingShingle Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
Iranzo, Alex
Trastorns del son
Demència amb cossos de Lewy
Malaltia de Parkinson
Sleep disorders
Lewy body dementia
Parkinson's disease
title_short Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
title_full Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
title_fullStr Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
title_full_unstemmed Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
title_sort Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder
dc.creator.none.fl_str_mv Iranzo, Alex
Mammana, Angela
Muñoz Lopetegi, Amaia
Dellavalle, Sofia
Mayà Casalprim, Gerard
Rossi, Marcello
Serradell, Mónica
Baiardi, Simone
Arqueros, Aurora
Quadalti, Corinne
Perissinotti, Andrés
Ruggeri, Edoardo
Santamaria Cano, Joan
Gaig Ventura, Carles
Parchi, Piero
author Iranzo, Alex
author_facet Iranzo, Alex
Mammana, Angela
Muñoz Lopetegi, Amaia
Dellavalle, Sofia
Mayà Casalprim, Gerard
Rossi, Marcello
Serradell, Mónica
Baiardi, Simone
Arqueros, Aurora
Quadalti, Corinne
Perissinotti, Andrés
Ruggeri, Edoardo
Santamaria Cano, Joan
Gaig Ventura, Carles
Parchi, Piero
author_role author
author2 Mammana, Angela
Muñoz Lopetegi, Amaia
Dellavalle, Sofia
Mayà Casalprim, Gerard
Rossi, Marcello
Serradell, Mónica
Baiardi, Simone
Arqueros, Aurora
Quadalti, Corinne
Perissinotti, Andrés
Ruggeri, Edoardo
Santamaria Cano, Joan
Gaig Ventura, Carles
Parchi, Piero
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorns del son
Demència amb cossos de Lewy
Malaltia de Parkinson
Sleep disorders
Lewy body dementia
Parkinson's disease
topic Trastorns del son
Demència amb cossos de Lewy
Malaltia de Parkinson
Sleep disorders
Lewy body dementia
Parkinson's disease
description Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies. We aimed to compare the ability of RT-QuIC to identify AS in the skin and CSF of patients with IRBD.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/220233
url https://hdl.handle.net/2445/220233
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1212/WNL.0000000000207147
Neurology, 2023, vol. 100, num.18, p. E1944-E1954
https://doi.org/10.1212/WNL.0000000000207147
dc.rights.none.fl_str_mv (c) American Academy of Neurology, 2023
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Academy of Neurology, 2023
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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