Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder

Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies....

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Detalles Bibliográficos
Autores: Iranzo, Alex, Mammana, Angela, Muñoz Lopetegi, Amaia, Dellavalle, Sofia, Mayà Casalprim, Gerard, Rossi, Marcello, Serradell, Mónica, Baiardi, Simone, Arqueros, Aurora, Quadalti, Corinne, Perissinotti, Andrés, Ruggeri, Edoardo, Santamaria Cano, Joan, Gaig Ventura, Carles, Parchi, Piero
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/220233
Acceso en línea:https://hdl.handle.net/2445/220233
Access Level:acceso abierto
Palabra clave:Trastorns del son
Demència amb cossos de Lewy
Malaltia de Parkinson
Sleep disorders
Lewy body dementia
Parkinson's disease
Descripción
Sumario:Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies. We aimed to compare the ability of RT-QuIC to identify AS in the skin and CSF of patients with IRBD.

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