Gut microbiota-related complications in cirrhosis

Gut microbiota plays an important role in cirrhosis. The liver is constantly challenged with commensal bacteria and their products arriving through the portal vein in the so-called gut-liver axis. Bacterial translocation from the intestinal lumen through the intestinal wall and to mesenteric lymph n...

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Detalles Bibliográficos
Autores: Gómez-Hurtado, Isabel, Such, José, Sanz Herranz, Yolanda, Francés, Rubén
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/220685
Acceso en línea:http://hdl.handle.net/10261/220685
Access Level:acceso abierto
Palabra clave:Cirrhosis
Encephalopathy
Portal hypertension
Spontaneous bacterial peritonitis
Microbiota
Bacterial translocation
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spelling Gut microbiota-related complications in cirrhosisGómez-Hurtado, IsabelSuch, JoséSanz Herranz, YolandaFrancés, RubénCirrhosisEncephalopathyPortal hypertensionSpontaneous bacterial peritonitisMicrobiotaBacterial translocationGut microbiota plays an important role in cirrhosis. The liver is constantly challenged with commensal bacteria and their products arriving through the portal vein in the so-called gut-liver axis. Bacterial translocation from the intestinal lumen through the intestinal wall and to mesenteric lymph nodes is facilitated by intestinal bacterial overgrowth, impairment in the permeability of the intestinal mucosal barrier, and deficiencies in local host immune defences. Deranged clearance of endogenous bacteria from portal and systemic circulation turns the gut into the major source of bacterialrelated complications. Liver function may therefore be affected by alterations in the composition of the intestinal microbiota and a role for commensal flora has been evidenced in the pathogenesis of several complications arising in end-stage liver disease such as hepatic encephalopathy, splanchnic arterial vasodilatation and spontaneous bacterial peritonitis. The use of antibiotics is the main therapeutic pipeline in the management of these bacteria-related complications. However, other strategies aimed at preserving intestinal homeostasis through the use of pre-, pro- or symbiotic formulations are being studied in the last years. In this review, the role of intestinal microbiota in the development of the most frequent complications arising in cirrhosis and the different clinical and experimental studies conducted to prevent or improve these complications by modifying the gut microbiota composition are summarized.Peer reviewedBaishideng Publishing GroupInstituto de Salud Carlos IIIMinisterio de Ciencia e Innovación (España)Sanz Herranz, Yolanda [0000-0002-1615-1976]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/220685reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2011-25169https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229527/Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2206852026-05-22T06:33:51Z
dc.title.none.fl_str_mv Gut microbiota-related complications in cirrhosis
title Gut microbiota-related complications in cirrhosis
spellingShingle Gut microbiota-related complications in cirrhosis
Gómez-Hurtado, Isabel
Cirrhosis
Encephalopathy
Portal hypertension
Spontaneous bacterial peritonitis
Microbiota
Bacterial translocation
title_short Gut microbiota-related complications in cirrhosis
title_full Gut microbiota-related complications in cirrhosis
title_fullStr Gut microbiota-related complications in cirrhosis
title_full_unstemmed Gut microbiota-related complications in cirrhosis
title_sort Gut microbiota-related complications in cirrhosis
dc.creator.none.fl_str_mv Gómez-Hurtado, Isabel
Such, José
Sanz Herranz, Yolanda
Francés, Rubén
author Gómez-Hurtado, Isabel
author_facet Gómez-Hurtado, Isabel
Such, José
Sanz Herranz, Yolanda
Francés, Rubén
author_role author
author2 Such, José
Sanz Herranz, Yolanda
Francés, Rubén
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Ministerio de Ciencia e Innovación (España)
Sanz Herranz, Yolanda [0000-0002-1615-1976]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cirrhosis
Encephalopathy
Portal hypertension
Spontaneous bacterial peritonitis
Microbiota
Bacterial translocation
topic Cirrhosis
Encephalopathy
Portal hypertension
Spontaneous bacterial peritonitis
Microbiota
Bacterial translocation
description Gut microbiota plays an important role in cirrhosis. The liver is constantly challenged with commensal bacteria and their products arriving through the portal vein in the so-called gut-liver axis. Bacterial translocation from the intestinal lumen through the intestinal wall and to mesenteric lymph nodes is facilitated by intestinal bacterial overgrowth, impairment in the permeability of the intestinal mucosal barrier, and deficiencies in local host immune defences. Deranged clearance of endogenous bacteria from portal and systemic circulation turns the gut into the major source of bacterialrelated complications. Liver function may therefore be affected by alterations in the composition of the intestinal microbiota and a role for commensal flora has been evidenced in the pathogenesis of several complications arising in end-stage liver disease such as hepatic encephalopathy, splanchnic arterial vasodilatation and spontaneous bacterial peritonitis. The use of antibiotics is the main therapeutic pipeline in the management of these bacteria-related complications. However, other strategies aimed at preserving intestinal homeostasis through the use of pre-, pro- or symbiotic formulations are being studied in the last years. In this review, the role of intestinal microbiota in the development of the most frequent complications arising in cirrhosis and the different clinical and experimental studies conducted to prevent or improve these complications by modifying the gut microbiota composition are summarized.
publishDate 2014
dc.date.none.fl_str_mv 2014
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/220685
url http://hdl.handle.net/10261/220685
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2011-25169
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229527/
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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