A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome

Purpose: To investigate the safety and efficacy of sterile isotonic seawater washes vs standard treatment with carmellose artificial tears in dry eye syndrome (DES). Patients and methods: This is a randomized multicenter prospective study with 12 weeks of follow-up. A group of patients with DES (N=...

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Autores: Diaz-Llopis M, Pinazo-Duran MD, Diaz-Guiñon L, Rahhal-Ortuño M, Perez-Ramos M, Bosch R, Gallego-Pinazo R, Dolz-Marco R, Diaz-Guiñon T, Diaz M, Romero FJ, Cisneros A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p3333
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/3333
Access Level:acceso abierto
Palabra clave:dry eye syndrome
isotonic seawater
artificial tears
carmellose
IL-1 beta
IL-6
quality of life
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spelling A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndromeDiaz-Llopis MPinazo-Duran MDDiaz-Guiñon LRahhal-Ortuño MPerez-Ramos MBosch RGallego-Pinazo RDolz-Marco RDiaz-Guiñon TDiaz MRomero FJCisneros Adry eye syndromeisotonic seawaterartificial tearscarmelloseIL-1 betaIL-6quality of lifePurpose: To investigate the safety and efficacy of sterile isotonic seawater washes vs standard treatment with carmellose artificial tears in dry eye syndrome (DES). Patients and methods: This is a randomized multicenter prospective study with 12 weeks of follow-up. A group of patients with DES (N= 60) were treated with seawater spray (Quinton (R)) five times daily, and another similar group (N= 60) were treated with carmellose artificial tears eyedrops (Viscofresh (R) 0.5%) five times a day. The parameters studied and measured were as follows: Ocular Surface Disease Index questionnaire score, Schirmer I test (without anesthesia) score, tear osmolarity (TearLab (R)), tear breakup time, tear meniscus height (meniscography OCT), fluorescein corneal staining score (National Eye Institute scale), lissamine green conjunctival staining score, and levels of IL-1 beta and IL-6 in tears (Luminex (R) 200). Results: In the group treated with seawater, symptoms decreased by 68%, and the decrease was 26% statistically superior to the group treated with carmellose artificial tears eyedrops (P<0.001). Levels of IL-1 beta and IL-6 in tears significantly decreased in the seawater group compared to the carmellose artificial tears group (19%/17% vs 52%/51%) (P<0.001). There were no statistically significant differences in the other measured parameters. There were no cases of poor tolerance or side effects. Conclusion: Administration of seawater is more effective than treatment with carmellose artificial tears in reducing symptoms and pro-inflammatory molecules (IL-1 beta and IL-6) in tears of patients with DES.DOVE MEDICAL PRESS LTD2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/3333Clinical OphthalmologyISSN: 11775483ISSNl: 11775467reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p33332026-06-11T12:45:17Z
dc.title.none.fl_str_mv A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome
title A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome
spellingShingle A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome
Diaz-Llopis M
dry eye syndrome
isotonic seawater
artificial tears
carmellose
IL-1 beta
IL-6
quality of life
title_short A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome
title_full A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome
title_fullStr A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome
title_full_unstemmed A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome
title_sort A randomized multicenter study comparing seawater washes and carmellose artificial tears eyedrops in the treatment of dry eye syndrome
dc.creator.none.fl_str_mv Diaz-Llopis M
Pinazo-Duran MD
Diaz-Guiñon L
Rahhal-Ortuño M
Perez-Ramos M
Bosch R
Gallego-Pinazo R
Dolz-Marco R
Diaz-Guiñon T
Diaz M
Romero FJ
Cisneros A
author Diaz-Llopis M
author_facet Diaz-Llopis M
Pinazo-Duran MD
Diaz-Guiñon L
Rahhal-Ortuño M
Perez-Ramos M
Bosch R
Gallego-Pinazo R
Dolz-Marco R
Diaz-Guiñon T
Diaz M
Romero FJ
Cisneros A
author_role author
author2 Pinazo-Duran MD
Diaz-Guiñon L
Rahhal-Ortuño M
Perez-Ramos M
Bosch R
Gallego-Pinazo R
Dolz-Marco R
Diaz-Guiñon T
Diaz M
Romero FJ
Cisneros A
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv dry eye syndrome
isotonic seawater
artificial tears
carmellose
IL-1 beta
IL-6
quality of life
topic dry eye syndrome
isotonic seawater
artificial tears
carmellose
IL-1 beta
IL-6
quality of life
description Purpose: To investigate the safety and efficacy of sterile isotonic seawater washes vs standard treatment with carmellose artificial tears in dry eye syndrome (DES). Patients and methods: This is a randomized multicenter prospective study with 12 weeks of follow-up. A group of patients with DES (N= 60) were treated with seawater spray (Quinton (R)) five times daily, and another similar group (N= 60) were treated with carmellose artificial tears eyedrops (Viscofresh (R) 0.5%) five times a day. The parameters studied and measured were as follows: Ocular Surface Disease Index questionnaire score, Schirmer I test (without anesthesia) score, tear osmolarity (TearLab (R)), tear breakup time, tear meniscus height (meniscography OCT), fluorescein corneal staining score (National Eye Institute scale), lissamine green conjunctival staining score, and levels of IL-1 beta and IL-6 in tears (Luminex (R) 200). Results: In the group treated with seawater, symptoms decreased by 68%, and the decrease was 26% statistically superior to the group treated with carmellose artificial tears eyedrops (P<0.001). Levels of IL-1 beta and IL-6 in tears significantly decreased in the seawater group compared to the carmellose artificial tears group (19%/17% vs 52%/51%) (P<0.001). There were no statistically significant differences in the other measured parameters. There were no cases of poor tolerance or side effects. Conclusion: Administration of seawater is more effective than treatment with carmellose artificial tears in reducing symptoms and pro-inflammatory molecules (IL-1 beta and IL-6) in tears of patients with DES.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/3333
url https://fisabio.portalinvestigacion.com/publicaciones/3333
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv DOVE MEDICAL PRESS LTD
publisher.none.fl_str_mv DOVE MEDICAL PRESS LTD
dc.source.none.fl_str_mv Clinical Ophthalmology
ISSN: 11775483
ISSNl: 11775467
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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