Tear Film Stabilization and Symptom Improvement in Dry Eye Disease: The Role of Hyaluronic Acid and Trehalose Eyedrops versus Carmellose Sodium

This study evaluated the effectiveness of hyaluronic acid and trehalose (HA/trehalose) eyedrops in managing dry eye disease (DED) symptoms by measuring tear stability and administering a DED questionnaire. Sixty patients were treated with either HA/trehalose eyedrops (Tear A) or carmellose sodium ey...

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Detalles Bibliográficos
Autores: Sánchez González, José María, Silva Viguera, María del Carmen, Sánchez González, María del Carmen, Capote Puente, Raúl, Hita Cantalejo, María Concepción de, Ballesteros Sánchez, Antonio, Ballesteros Durán, Lydia, García Romera, Marta de la Concepción, Gutiérrez Sánchez, Estanislao
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/151088
Acceso en línea:https://hdl.handle.net/11441/151088
https://doi.org/10.3390/jcm12206647
Access Level:acceso abierto
Palabra clave:Artificial tears
Carmellose sodium
Dry eye disease
Hyaluronic acid
Non-invasive breakup time
Standard patient evaluation of eye dryness
Symptom management
Tear breakup time
Tear film stability
Trehalose
Descripción
Sumario:This study evaluated the effectiveness of hyaluronic acid and trehalose (HA/trehalose) eyedrops in managing dry eye disease (DED) symptoms by measuring tear stability and administering a DED questionnaire. Sixty patients were treated with either HA/trehalose eyedrops (Tear A) or carmellose sodium eyedrops (Tear B) as controls. The tear breakup time (TBUT) and non-invasive breakup time (NIBUT) were monitored, and patients completed the standard patient evaluation of eye dryness (SPEED) questionnaire. After two months of twice-daily applications, patients treated with the HA/trehalose eyedrops demonstrated significant improvements in the NIBUT (12.98 ± 3.22 s) and TBUT (12.95 ± 2.98 s), indicating increased tear stability. Moreover, they reported lower dry eye sensation (6.70 ± 4.94 SPEED score points), suggesting a reduction in DED symptoms. These findings underscore the efficacy of HA/trehalose eyedrops in improving both the objective and subjective signs of DED, with twice-daily application enhancing ocular surface conditions and reducing patient-reported symptoms. © 2023 by the authors.

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