A novel role for lncRNAs in cell cycle control during stress adaptation

Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression in response to environmental changes. In response to extracellular insults, str...

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Detalles Bibliográficos
Autores: Solé, Carme, Nadal Ribelles, Mariona, 1984-, Nadal Clanchet, Eulàlia de, Posas Garriga, Francesc
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/23726
Acceso en línea:http://hdl.handle.net/10230/23726
http://dx.doi.org/10.1007/s00294-014-0453-y
Access Level:acceso abierto
Palabra clave:RNA
SAPKs
Hog1
Osmostress
LncRNA
Gene expression
Cell cycle
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spelling A novel role for lncRNAs in cell cycle control during stress adaptationSolé, CarmeNadal Ribelles, Mariona, 1984-Nadal Clanchet, Eulàlia dePosas Garriga, FrancescRNASAPKsHog1OsmostressLncRNAGene expressionCell cycleEukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression in response to environmental changes. In response to extracellular insults, stress-activated protein kinases (SAPKs) modulate cell-cycle progression and gene expression. In yeast, osmostress induces activation of the p38-related SAPK Hog1, which plays a key role in reprogramming gene expression upon osmostress. Genomic analysis has revealed the existence of a large number of long non-coding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Upon osmostress, hundreds of lncRNAs are induced by the SAPK p38/Hog1. One gene that expresses Hog1-dependent lncRNA in an antisense orientation is the CDC28 gene, which encodes CDK1 kinase that controls the cell cycle in yeast. Cdc28 lncRNA mediates the induction of CDC28 expression and this increase in the level of Cdc28 results in more efficient re-entry of the cells into the cell cycle after stress. Thus, the control of lncRNA expression as a new mechanism for the regulation of cell-cycle progression opens new avenues to understand how stress adaptation can be accomplished in response to changing environments.The laboratory of FP and EN is supported by grants from the Spanish Government (BFU2012-33503 and FEDER to FP, BFU2011-26722 to EN), an ERC Advanced Grant Number 294294 from the EU seventh framework program (SYNCOM) and the Fundación Marcelino Botín (FMB) to FP. FP and EN are recipients of an ICREA Acadèmia (Generalitat de Catalunya). The authors declare no competing financial interestSpringer201520152015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23726http://dx.doi.org/10.1007/s00294-014-0453-yreponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCurrent Genetics. 2015;61(3):299-308info:eu-repo/grantAgreement/EC/FP7/294294info:eu-repo/grantAgreement/ES/3PN/BFU2012-33503info:eu-repo/grantAgreement/ES/3PN/BFU2011-26722© The Author(s) 2014. This article is published with open access at Springerlink.cominfo:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/237262026-06-12T07:21:37Z
dc.title.none.fl_str_mv A novel role for lncRNAs in cell cycle control during stress adaptation
title A novel role for lncRNAs in cell cycle control during stress adaptation
spellingShingle A novel role for lncRNAs in cell cycle control during stress adaptation
Solé, Carme
RNA
SAPKs
Hog1
Osmostress
LncRNA
Gene expression
Cell cycle
title_short A novel role for lncRNAs in cell cycle control during stress adaptation
title_full A novel role for lncRNAs in cell cycle control during stress adaptation
title_fullStr A novel role for lncRNAs in cell cycle control during stress adaptation
title_full_unstemmed A novel role for lncRNAs in cell cycle control during stress adaptation
title_sort A novel role for lncRNAs in cell cycle control during stress adaptation
dc.creator.none.fl_str_mv Solé, Carme
Nadal Ribelles, Mariona, 1984-
Nadal Clanchet, Eulàlia de
Posas Garriga, Francesc
author Solé, Carme
author_facet Solé, Carme
Nadal Ribelles, Mariona, 1984-
Nadal Clanchet, Eulàlia de
Posas Garriga, Francesc
author_role author
author2 Nadal Ribelles, Mariona, 1984-
Nadal Clanchet, Eulàlia de
Posas Garriga, Francesc
author2_role author
author
author
dc.subject.none.fl_str_mv RNA
SAPKs
Hog1
Osmostress
LncRNA
Gene expression
Cell cycle
topic RNA
SAPKs
Hog1
Osmostress
LncRNA
Gene expression
Cell cycle
description Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression in response to environmental changes. In response to extracellular insults, stress-activated protein kinases (SAPKs) modulate cell-cycle progression and gene expression. In yeast, osmostress induces activation of the p38-related SAPK Hog1, which plays a key role in reprogramming gene expression upon osmostress. Genomic analysis has revealed the existence of a large number of long non-coding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Upon osmostress, hundreds of lncRNAs are induced by the SAPK p38/Hog1. One gene that expresses Hog1-dependent lncRNA in an antisense orientation is the CDC28 gene, which encodes CDK1 kinase that controls the cell cycle in yeast. Cdc28 lncRNA mediates the induction of CDC28 expression and this increase in the level of Cdc28 results in more efficient re-entry of the cells into the cell cycle after stress. Thus, the control of lncRNA expression as a new mechanism for the regulation of cell-cycle progression opens new avenues to understand how stress adaptation can be accomplished in response to changing environments.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/23726
http://dx.doi.org/10.1007/s00294-014-0453-y
url http://hdl.handle.net/10230/23726
http://dx.doi.org/10.1007/s00294-014-0453-y
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Current Genetics. 2015;61(3):299-308
info:eu-repo/grantAgreement/EC/FP7/294294
info:eu-repo/grantAgreement/ES/3PN/BFU2012-33503
info:eu-repo/grantAgreement/ES/3PN/BFU2011-26722
dc.rights.none.fl_str_mv © The Author(s) 2014. This article is published with open access at Springerlink.com
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © The Author(s) 2014. This article is published with open access at Springerlink.com
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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