Sam68 and circRNA biogenesis in early development

During the last decades the non-coding portion of the genome became subject of intense research due to its contribution to the complexity of biological and pathological processes. CircRNAs are a class of non-coding RNAs able to influence gene expression during development and their biogenesis relies...

Descripción completa

Detalles Bibliográficos
Autor: Antonelli, Maria Carla
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/671430
Acceso en línea:http://hdl.handle.net/10803/671430
Access Level:acceso abierto
Palabra clave:CircRNAs
Sam68
Development
RBP
mESCs
STAR RBPs
Desarrollo
575
id ES_1e4a484909836a7f830ca36a4aaf3d4e
oai_identifier_str oai:www.tdx.cat:10803/671430
network_acronym_str ES
network_name_str España
repository_id_str
spelling Sam68 and circRNA biogenesis in early developmentAntonelli, Maria CarlaCircRNAsSam68DevelopmentRBPmESCsSTAR RBPsDesarrollo575During the last decades the non-coding portion of the genome became subject of intense research due to its contribution to the complexity of biological and pathological processes. CircRNAs are a class of non-coding RNAs able to influence gene expression during development and their biogenesis relies on the activity of several RBPs. Indeed, the Signal Transduction and Activation of RNA (STAR) family members Quaking and Sam68 have been shown to be involved in the biogenesis of circRNAs in specific biological contexts, but whether their contribution is extended to embryonic development is unknown. Our evidences suggest that Sam68 is involved in circRNA biogenesis during differentiation towards cardiac lineage, providing a new layer of regulation during embryonic development.Durante las últimas décadas, la parte no codificante del genoma se ha convertido en objeto de intensa investigación debido a su contribución a la complejidad de los procesos biológicos y patológicos. Los CircRNAs son una clase de RNA no codificante capaces de influir en la expresión génica durante el desarrollo y su biogénesis se basa en la actividad de varias proteínas que ligan el RNA llamadas RNA-Binding Proteins (RBPs). Se ha demostrado que varias RBPs están implicadas en la biogénesis de los circRNAs, especialmente Quaking y Sam68, miembros de la familia STAR (Signal Transduction and Activation of RNA) pero se desconoce si su contribución se extiende al desarrollo embrionario. Mi proyecto de doctorado tiene como objetivo desenredar esta brecha definiendo el papel de Sam68 en la biogénesis de circRNAs durante la diferenciación de células madre embrionarias (mESCs).Programa de doctorat en BiomedicinaTartaglia, Gian GaetanoBechara, EliasUniversitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut202120232021info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion150 p.application/pdfapplication/pdfhttp://hdl.handle.net/10803/671430TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésADVERTIMENT. Tots els drets reservats. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6714302026-06-14T12:46:07Z
dc.title.none.fl_str_mv Sam68 and circRNA biogenesis in early development
title Sam68 and circRNA biogenesis in early development
spellingShingle Sam68 and circRNA biogenesis in early development
Antonelli, Maria Carla
CircRNAs
Sam68
Development
RBP
mESCs
STAR RBPs
Desarrollo
575
title_short Sam68 and circRNA biogenesis in early development
title_full Sam68 and circRNA biogenesis in early development
title_fullStr Sam68 and circRNA biogenesis in early development
title_full_unstemmed Sam68 and circRNA biogenesis in early development
title_sort Sam68 and circRNA biogenesis in early development
dc.creator.none.fl_str_mv Antonelli, Maria Carla
author Antonelli, Maria Carla
author_facet Antonelli, Maria Carla
author_role author
dc.contributor.none.fl_str_mv Tartaglia, Gian Gaetano
Bechara, Elias
Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
dc.subject.none.fl_str_mv CircRNAs
Sam68
Development
RBP
mESCs
STAR RBPs
Desarrollo
575
topic CircRNAs
Sam68
Development
RBP
mESCs
STAR RBPs
Desarrollo
575
description During the last decades the non-coding portion of the genome became subject of intense research due to its contribution to the complexity of biological and pathological processes. CircRNAs are a class of non-coding RNAs able to influence gene expression during development and their biogenesis relies on the activity of several RBPs. Indeed, the Signal Transduction and Activation of RNA (STAR) family members Quaking and Sam68 have been shown to be involved in the biogenesis of circRNAs in specific biological contexts, but whether their contribution is extended to embryonic development is unknown. Our evidences suggest that Sam68 is involved in circRNA biogenesis during differentiation towards cardiac lineage, providing a new layer of regulation during embryonic development.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/671430
url http://hdl.handle.net/10803/671430
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 150 p.
application/pdf
application/pdf
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404328296448000
score 15,301629

Similares en LA Referencia