Sam68 and circRNA biogenesis in early development
During the last decades the non-coding portion of the genome became subject of intense research due to its contribution to the complexity of biological and pathological processes. CircRNAs are a class of non-coding RNAs able to influence gene expression during development and their biogenesis relies...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/671430 |
| Acceso en línea: | http://hdl.handle.net/10803/671430 |
| Access Level: | acceso abierto |
| Palabra clave: | CircRNAs Sam68 Development RBP mESCs STAR RBPs Desarrollo 575 |
| Sumario: | During the last decades the non-coding portion of the genome became subject of intense research due to its contribution to the complexity of biological and pathological processes. CircRNAs are a class of non-coding RNAs able to influence gene expression during development and their biogenesis relies on the activity of several RBPs. Indeed, the Signal Transduction and Activation of RNA (STAR) family members Quaking and Sam68 have been shown to be involved in the biogenesis of circRNAs in specific biological contexts, but whether their contribution is extended to embryonic development is unknown. Our evidences suggest that Sam68 is involved in circRNA biogenesis during differentiation towards cardiac lineage, providing a new layer of regulation during embryonic development. |
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