Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry

To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, h...

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Bibliographic Details
Authors: Molina-Collada, Juan, Domínguez-Álvaro, Marta, Melero-González, Rafael B, de Miguel, Eugenio, Silva-Díaz, Maite, Valero Jaimes, Jesús Alejandro, González, Ismael, Sánchez Martín, Julio, Narváez, Javier, Calvet, Joan, Casafont-Solé, Ivette, Román Ivorra, Jose A, Labrada Arrabal, Selene, Vasques Rocha, Margarida, Iñiguez, Carlota L, Bustabad Reyes, María Sagrario, Campos Fernández, Cristina, Alcalde Villar, María, Juan Mas, Antonio, Blanco, Ricardo
Format: article
Publication Date:2025
Country:España
Institution:Conselleria de Salut i Consum del Govern de les Illes Balears
Repository:Docusalut
Language:English
OAI Identifier:oai:docusalut.com:20.500.13003/21590
Online Access:https://hdl.handle.net/20.500.13003/21590
Access Level:Open access
Keyword:Aged, 80 and over
Aged
Male
Giant Cell Arteritis
Spain
Female
Humans
Registries
Middle Aged
Retrospective Studies
Humanos
Persona de Mediana Edad
Arteritis de Células Gigantes
Anciano
Anciano de 80 o más Años
Femenino
Estudios Retrospectivos
España
Sistema de Registros
Masculino
Description
Summary:To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.

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