Pacientes con Gripe por Virus Influenza A (H1N1)pdm09 ingresados en UCI. Impacto de las Recomendaciones de la SEMICYUC

OBJECTIVES: To evaluate the impact of the recommendations of the SEMICYUC (2012) on severe influenza A. DESIGN: A prospective multicenter observational study was carried out. SETTING: ICU. PATIENTS: Patients infected with severe influenza A (H1N1) from the GETGAG/SEMICYUC registry. INTERVENTIONS: An...

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Bibliographic Details
Authors: Marin Corral, Judith, Climent Company, María Cristina, Muñoz Bermudez, Rosana, Samper Echevarria, Maria, Dot Jordana, Irene, 1982-, Vilà Vilardell, Clara, Masclans Enviz, Joan Ramon, Rodríguez, Alejandro, Martín Loeches, Ignacio, Álvarez Lerma, Francisco, H1N1 GETGAG/SEMICYUC Study Group
Format: article
Status:Versión aceptada para publicación
Publication Date:2018
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/36036
Online Access:http://hdl.handle.net/10230/36036
http://dx.doi.org/10.1016/j.medin.2018.02.002
Access Level:Open access
Keyword:Grip A (H1N1)
Critically illness
Enfermedad crítica
Infección por virus influenza A (H1N1)pdm09
Influenza A (H1N1)pdm09 virus infection
Intensive Care Unit
Manejo terapéutico
Mortalidad
Mortality
Outcome
Pronóstico
Therapeutic management
Unidad de Cuidados Intensivos
Description
Summary:OBJECTIVES: To evaluate the impact of the recommendations of the SEMICYUC (2012) on severe influenza A. DESIGN: A prospective multicenter observational study was carried out. SETTING: ICU. PATIENTS: Patients infected with severe influenza A (H1N1) from the GETGAG/SEMICYUC registry. INTERVENTIONS: Analysis of 2 groups according to the epidemic period of the diagnosis (2009-2011; 2013-2015). VARIABLES: Demographic, temporal, comorbidities, severity, treatments, mortality, late diagnosis and place of acquisition. RESULTS: A total of 2,205 patients were included, 1,337 (60.6%) in the first period and 868 (39.4%) in the second one. Age and severity on admission were significantly greater in the second period, as well as co-infection. With regard to the impact of the recommendations, in the second period the diagnosis was established earlier (70.8 vs. 61.1%, P<.001), without changes in the start of treatment. Patients received less corticosteroid treatment (39.7 vs. 44.9%, P<.05), more NIMV was used (47.4 vs. 33.2%, P<.001) and more vaccination was made (11.1 vs. 1.7%, P<.001), without changes in mortality (24.2 vs. 20.7%). A decrease in nosocomial infection was also noted (9.8 vs. 16%, P<.001). Patients needed less MV with more days of ventilation, more vasopressor drug use and more ventral decubitus. CONCLUSIONS: The management of patients with severe influenza A (H1N1) has changed over the years, though without changes in mortality. The recommendations of the SEMICYUC (2012) have allowed earlier diagnosis and improved corticosteroid use. Pending challenges are the delay in treatment, the vaccination rate and the use of NIMV.

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