Expansion of influenza A(H1N1)pdm09 NA:S247N viruses with reduced susceptibility to oseltamivir, Catalonia, Spain, and in Europe, July to October 2025

Between July and October 2025, among the total 117 influenza A(H1N1)pdm09 strains characterised in Catalonia, 20% to 100% per week were carrying the NA:S247N substitution. The mutation, conferring reduced susceptibility to oseltamivir, was phenotypically confirmed (IC between 0.82 and 1.63 nM, compa...

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Detalles Bibliográficos
Autores: Saubi, Narcis|||0000-0001-5493-1044, Andrés, Cristina|||0000-0002-3200-0895, Prats-Méndez, Ignasi, González Sánchez, Alejandra|||0000-0002-1809-3415, Davtyan, Alysa, Vásquez-Mercado, Rodrigo, Rando-Segura, Ariadna|||0000-0003-4555-7286, Nadal-Barón, Patricia|||0000-0002-2656-2656, Esperalba, Juliana|||0000-0003-1326-1341, Arnedo, Maria|||0000-0002-8015-5170, Vicente, Marina, Balada, Eva, Mendioroz Peña, Jacobo|||0000-0002-8883-2180, Martín, Maria Carmen, García-Comuñas, Karen, Vaz, Raquel, Najarro-Centeno, Adrián, Bernalte, Susana, Larrosa, María Nieves|||0000-0001-8808-0233, Antón Pagarolas, Andrés, 1976-|||0000-0002-1476-0815
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:dnet:uabarcelona_::f89a8462465fa9e74f348ca27a9755b2
Acceso en línea:https://ddd.uab.cat/record/328464
https://dx.doi.org/urn:doi:10.2807/1560-7917.ES.2025.30.48.2500873
Access Level:acceso abierto
Palabra clave:Influenza
S247N
Neuraminidase
Oseltamivir
A(H1N1)pdm09
Catalonia
Spain
Descripción
Sumario:Between July and October 2025, among the total 117 influenza A(H1N1)pdm09 strains characterised in Catalonia, 20% to 100% per week were carrying the NA:S247N substitution. The mutation, conferring reduced susceptibility to oseltamivir, was phenotypically confirmed (IC between 0.82 and 1.63 nM, compared to median IC of 0.3 nM for susceptible strains). An increased proportion of S247N variants was also observed in sequence data (10,944 sequences) from other parts of Spain and five of 35 submitting countries across Europe.

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