Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy

Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represen...

Descripción completa

Detalles Bibliográficos
Autores: Linares, Jenniffer, Marín Jiménez, Juan A., Badia Ramentol, Jordi, Calon, Alexandre
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174366
Acceso en línea:https://hdl.handle.net/2445/174366
Access Level:acceso abierto
Palabra clave:Càncer
Tractament adjuvant del càncer
Metàstasi
Cancer
Adjuvant treatment of cancer
Metastasis
id ES_1de1e2cb2caedeea16b728ef13e157b6
oai_identifier_str oai:recercat.cat:2445/174366
network_acronym_str ES
network_name_str España
repository_id_str
spelling Determinants and Functions of CAFs Secretome During Cancer Progression and TherapyLinares, JennifferMarín Jiménez, Juan A.Badia Ramentol, JordiCalon, AlexandreCàncerTractament adjuvant del càncerMetàstasiCancerAdjuvant treatment of cancerMetastasisMultiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.Frontiers Media2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion19 p.application/pdfhttps://hdl.handle.net/2445/174366Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fcell.2020.621070Frontiers in Cell and Developmental Biology, 2021, vol. 8https://doi.org/10.3389/fcell.2020.621070cc by (c) Linares et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1743662026-05-29T05:05:01Z
dc.title.none.fl_str_mv Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
title Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
spellingShingle Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
Linares, Jenniffer
Càncer
Tractament adjuvant del càncer
Metàstasi
Cancer
Adjuvant treatment of cancer
Metastasis
title_short Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
title_full Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
title_fullStr Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
title_full_unstemmed Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
title_sort Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
dc.creator.none.fl_str_mv Linares, Jenniffer
Marín Jiménez, Juan A.
Badia Ramentol, Jordi
Calon, Alexandre
author Linares, Jenniffer
author_facet Linares, Jenniffer
Marín Jiménez, Juan A.
Badia Ramentol, Jordi
Calon, Alexandre
author_role author
author2 Marín Jiménez, Juan A.
Badia Ramentol, Jordi
Calon, Alexandre
author2_role author
author
author
dc.subject.none.fl_str_mv Càncer
Tractament adjuvant del càncer
Metàstasi
Cancer
Adjuvant treatment of cancer
Metastasis
topic Càncer
Tractament adjuvant del càncer
Metàstasi
Cancer
Adjuvant treatment of cancer
Metastasis
description Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174366
url https://hdl.handle.net/2445/174366
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fcell.2020.621070
Frontiers in Cell and Developmental Biology, 2021, vol. 8
https://doi.org/10.3389/fcell.2020.621070
dc.rights.none.fl_str_mv cc by (c) Linares et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Linares et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 19 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404305291739136
score 15.81155

Similares en LA Referencia