PsyCog: A computerised mini battery for assessing cognition in psychosis
Despite the functional impact of cognitive deficit in people with psychosis, objective cognitive assessment is not typically part of routine clinical care. This is partly due to the length of traditional assessments and the need for a highly trained administrator. Brief, automated computerised asses...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/388325 |
| Acesso em linha: | http://hdl.handle.net/10261/388325 |
| Access Level: | acceso abierto |
| Palavra-chave: | Psychosis Cognition First episode psychosis Clinical high risk for psychosis |
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PsyCog: A computerised mini battery for assessing cognition in psychosisGifford, GeorgeCullen, Alexis E.Vieira, SandraSearle, AnjaMcCutcheon, Robert A.Modinos, GemmaStone, William S.Hird, EmilyBarnett, Jennifervan Hell, Hendrika H.Catalán, AnaMillgate, EdwardTaptiklis, NickCormack, FrancescaSlot, Margot I. E.Dazzan, PaolaMaat, Arijade Haan, LieuweCrespo-Facorro, BenedictoGlenthøj, BirteLawrie, Stephen M.McDonald, ColmGruber, Olivervan Amelsvoort, ThérèseArango, CelsoKircher, TiloNelson, BarnabyGalderisi, SilvanaBressan, Rodrigo A.Kwon, Jun SooWeiser, MarkMizrahi, RominaSachs, GabrieleKirschner, MatthiasReichenberg, AbrahamKahn, RenéMcGuire, PhilipPsychosisCognitionFirst episode psychosisClinical high risk for psychosisDespite the functional impact of cognitive deficit in people with psychosis, objective cognitive assessment is not typically part of routine clinical care. This is partly due to the length of traditional assessments and the need for a highly trained administrator. Brief, automated computerised assessments could help to address this issue. We present data from an evaluation of PsyCog, a computerised, non-verbal, mini battery of cognitive tests. Healthy Control (HC) (N = 135), Clinical High Risk (CHR) (N = 233), and First Episode Psychosis (FEP) (N = 301) participants from a multi-centre prospective study were assessed at baseline, 6 months, and 12 months. PsyCog was used to assess cognitive performance at baseline and at up to two follow-up timepoints. Mean total testing time was 35.95 min (SD = 2.87). Relative to HCs, effect sizes of performance impairments were medium to large in FEP patients (composite score G = 1.21, subtest range = 0.52–0.88) and small to medium in CHR patients (composite score G = 0.59, subtest range = 0.18–0.49). Site effects were minimal, and test-retest reliability of the PsyCog composite was good (ICC = 0.82–0.89), though some practice effects and differences in data completion between groups were found. The present implementation of PsyCog shows it to be a useful tool for assessing cognitive function in people with psychosis. Computerised cognitive assessments have the potential to facilitate the evaluation of cognition in psychosis in both research and in clinical care, though caution should still be taken in terms of implementation and study design.The PSYSCAN project is funded by the European Commission within its 7th Framework Programme under grant agreement number 603196: PSYSCAN – Translating neuroimaging findings from research into clinical practice. RAMs work is funded by a Wellcome Trust Clinical Research Career Development (224625/Z/21/Z)Peer reviewedElsevierEuropean CommissionWellcome TrustConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/388325reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/603196The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1016/j.scog.2024.100310https://doi.org/10.1016/j.scog.2024.100310Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3883252026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
PsyCog: A computerised mini battery for assessing cognition in psychosis |
| title |
PsyCog: A computerised mini battery for assessing cognition in psychosis |
| spellingShingle |
PsyCog: A computerised mini battery for assessing cognition in psychosis Gifford, George Psychosis Cognition First episode psychosis Clinical high risk for psychosis |
| title_short |
PsyCog: A computerised mini battery for assessing cognition in psychosis |
| title_full |
PsyCog: A computerised mini battery for assessing cognition in psychosis |
| title_fullStr |
PsyCog: A computerised mini battery for assessing cognition in psychosis |
| title_full_unstemmed |
PsyCog: A computerised mini battery for assessing cognition in psychosis |
| title_sort |
PsyCog: A computerised mini battery for assessing cognition in psychosis |
| dc.creator.none.fl_str_mv |
Gifford, George Cullen, Alexis E. Vieira, Sandra Searle, Anja McCutcheon, Robert A. Modinos, Gemma Stone, William S. Hird, Emily Barnett, Jennifer van Hell, Hendrika H. Catalán, Ana Millgate, Edward Taptiklis, Nick Cormack, Francesca Slot, Margot I. E. Dazzan, Paola Maat, Arija de Haan, Lieuwe Crespo-Facorro, Benedicto Glenthøj, Birte Lawrie, Stephen M. McDonald, Colm Gruber, Oliver van Amelsvoort, Thérèse Arango, Celso Kircher, Tilo Nelson, Barnaby Galderisi, Silvana Bressan, Rodrigo A. Kwon, Jun Soo Weiser, Mark Mizrahi, Romina Sachs, Gabriele Kirschner, Matthias Reichenberg, Abraham Kahn, René McGuire, Philip |
| author |
Gifford, George |
| author_facet |
Gifford, George Cullen, Alexis E. Vieira, Sandra Searle, Anja McCutcheon, Robert A. Modinos, Gemma Stone, William S. Hird, Emily Barnett, Jennifer van Hell, Hendrika H. Catalán, Ana Millgate, Edward Taptiklis, Nick Cormack, Francesca Slot, Margot I. E. Dazzan, Paola Maat, Arija de Haan, Lieuwe Crespo-Facorro, Benedicto Glenthøj, Birte Lawrie, Stephen M. McDonald, Colm Gruber, Oliver van Amelsvoort, Thérèse Arango, Celso Kircher, Tilo Nelson, Barnaby Galderisi, Silvana Bressan, Rodrigo A. Kwon, Jun Soo Weiser, Mark Mizrahi, Romina Sachs, Gabriele Kirschner, Matthias Reichenberg, Abraham Kahn, René McGuire, Philip |
| author_role |
author |
| author2 |
Cullen, Alexis E. Vieira, Sandra Searle, Anja McCutcheon, Robert A. Modinos, Gemma Stone, William S. Hird, Emily Barnett, Jennifer van Hell, Hendrika H. Catalán, Ana Millgate, Edward Taptiklis, Nick Cormack, Francesca Slot, Margot I. E. Dazzan, Paola Maat, Arija de Haan, Lieuwe Crespo-Facorro, Benedicto Glenthøj, Birte Lawrie, Stephen M. McDonald, Colm Gruber, Oliver van Amelsvoort, Thérèse Arango, Celso Kircher, Tilo Nelson, Barnaby Galderisi, Silvana Bressan, Rodrigo A. Kwon, Jun Soo Weiser, Mark Mizrahi, Romina Sachs, Gabriele Kirschner, Matthias Reichenberg, Abraham Kahn, René McGuire, Philip |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
European Commission Wellcome Trust Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Psychosis Cognition First episode psychosis Clinical high risk for psychosis |
| topic |
Psychosis Cognition First episode psychosis Clinical high risk for psychosis |
| description |
Despite the functional impact of cognitive deficit in people with psychosis, objective cognitive assessment is not typically part of routine clinical care. This is partly due to the length of traditional assessments and the need for a highly trained administrator. Brief, automated computerised assessments could help to address this issue. We present data from an evaluation of PsyCog, a computerised, non-verbal, mini battery of cognitive tests. Healthy Control (HC) (N = 135), Clinical High Risk (CHR) (N = 233), and First Episode Psychosis (FEP) (N = 301) participants from a multi-centre prospective study were assessed at baseline, 6 months, and 12 months. PsyCog was used to assess cognitive performance at baseline and at up to two follow-up timepoints. Mean total testing time was 35.95 min (SD = 2.87). Relative to HCs, effect sizes of performance impairments were medium to large in FEP patients (composite score G = 1.21, subtest range = 0.52–0.88) and small to medium in CHR patients (composite score G = 0.59, subtest range = 0.18–0.49). Site effects were minimal, and test-retest reliability of the PsyCog composite was good (ICC = 0.82–0.89), though some practice effects and differences in data completion between groups were found. The present implementation of PsyCog shows it to be a useful tool for assessing cognitive function in people with psychosis. Computerised cognitive assessments have the potential to facilitate the evaluation of cognition in psychosis in both research and in clinical care, though caution should still be taken in terms of implementation and study design. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/388325 |
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http://hdl.handle.net/10261/388325 |
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Inglés |
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Inglés |
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#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/FP7/603196 The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1016/j.scog.2024.100310 https://doi.org/10.1016/j.scog.2024.100310 Sí |
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Elsevier |
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Elsevier |
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