PsyCog: A computerised mini battery for assessing cognition in psychosis

Despite the functional impact of cognitive deficit in people with psychosis, objective cognitive assessment is not typically part of routine clinical care. This is partly due to the length of traditional assessments and the need for a highly trained administrator. Brief, automated computerised asses...

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Bibliographic Details
Authors: Gifford, George, Cullen, Alexis E., Vieira, Sandra, Searle, Anja, McCutcheon, Robert A., Modinos, Gemma, Stone, William S., Hird, Emily, Barnett, Jennifer, van Hell, Hendrika H., Catalán, Ana, Millgate, Edward, Taptiklis, Nick, Cormack, Francesca, Slot, Margot I. E., Dazzan, Paola, Maat, Arija, de Haan, Lieuwe, Crespo-Facorro, Benedicto, Glenthøj, Birte, Lawrie, Stephen M., McDonald, Colm, Gruber, Oliver, van Amelsvoort, Thérèse, Arango, Celso, Kircher, Tilo, Nelson, Barnaby, Galderisi, Silvana, Bressan, Rodrigo A., Kwon, Jun Soo, Weiser, Mark, Mizrahi, Romina, Sachs, Gabriele, Kirschner, Matthias, Reichenberg, Abraham, Kahn, René, McGuire, Philip
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/388325
Online Access:http://hdl.handle.net/10261/388325
Access Level:Open access
Keyword:Psychosis
Cognition
First episode psychosis
Clinical high risk for psychosis
Description
Summary:Despite the functional impact of cognitive deficit in people with psychosis, objective cognitive assessment is not typically part of routine clinical care. This is partly due to the length of traditional assessments and the need for a highly trained administrator. Brief, automated computerised assessments could help to address this issue. We present data from an evaluation of PsyCog, a computerised, non-verbal, mini battery of cognitive tests. Healthy Control (HC) (N = 135), Clinical High Risk (CHR) (N = 233), and First Episode Psychosis (FEP) (N = 301) participants from a multi-centre prospective study were assessed at baseline, 6 months, and 12 months. PsyCog was used to assess cognitive performance at baseline and at up to two follow-up timepoints. Mean total testing time was 35.95 min (SD = 2.87). Relative to HCs, effect sizes of performance impairments were medium to large in FEP patients (composite score G = 1.21, subtest range = 0.52–0.88) and small to medium in CHR patients (composite score G = 0.59, subtest range = 0.18–0.49). Site effects were minimal, and test-retest reliability of the PsyCog composite was good (ICC = 0.82–0.89), though some practice effects and differences in data completion between groups were found. The present implementation of PsyCog shows it to be a useful tool for assessing cognitive function in people with psychosis. Computerised cognitive assessments have the potential to facilitate the evaluation of cognition in psychosis in both research and in clinical care, though caution should still be taken in terms of implementation and study design.

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