Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy

Lung stereotactic body radiation therapy (SBRT) is associated with sources of geometric uncertainties, such as respiratory motion, daily anatomical variations (anatomical baseline shifts between daily and planned position) and the simultaneous movement between the tumor and the multileaf collimator...

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Detalhes bibliográficos
Autor: Huesa-Berral, C. (Carlos)|||/items/d2c35b31-4cf0-437c-aeff-d47b8a0f6fb6
Tipo de documento: tese
Data de publicação:2021
País:España
Recursos:Universidad de Navarra
Repositório:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglês
OAI Identifier:oai:dadun.unav.edu:10171/65036
Acesso em linha:https://hdl.handle.net/10171/65036
Access Level:Acceso aberto
Palavra-chave:Materias Investigacion::Física
Lung cancer
Radiotherapy
Stereotactic body radiation therapy
Cáncer de pulmón
Radioterapia
Radioterapia corporal estereotáctica
id ES_1dca68dc4637d8fde791b00da7e43ea0
oai_identifier_str oai:dadun.unav.edu:10171/65036
network_acronym_str ES
network_name_str España
repository_id_str
spelling Quantification of dosimetric uncertainties in lung stereotactic body radiation therapyHuesa-Berral, C. (Carlos)|||/items/d2c35b31-4cf0-437c-aeff-d47b8a0f6fb6Materias Investigacion::FísicaLung cancerRadiotherapyStereotactic body radiation therapyCáncer de pulmónRadioterapiaRadioterapia corporal estereotácticaLung stereotactic body radiation therapy (SBRT) is associated with sources of geometric uncertainties, such as respiratory motion, daily anatomical variations (anatomical baseline shifts between daily and planned position) and the simultaneous movement between the tumor and the multileaf collimator (the so-called interplay effect) during treatment delivery. In this work, several methodologies have been implemented based on deformable image registration to quantify the dosimetric impact of those geometric uncertainties in lung SBRT. These methodologies revealed two main conclusions: First, daily anatomical deviations in patient anatomy generally had a larger dosimetric impact than respiratory motion. Second, the impact of interplay effect could be a concern for highly irregular patient breathing patterns or for long breathing periods, and whether small field size were used for dose conformation purposes. Furthermore, these methodologies developed would be very helpful for clinicians involved in treatment planning and delivery to evaluate treatment robustness against the geometric uncertainties studied in this work.Universidad de NavarraBurguete-Mas, F.J. (Francisco Javier)Azcona-Armendariz, J.D. (Juan Diego)Dadun. Depósito Académico Digital Universidad de Navarra20232023-01-2320232023-01-2320232023-01-2320212021-09-13doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/10171/65036reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/650362026-06-21T12:47:57Z
dc.title.none.fl_str_mv Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
title Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
spellingShingle Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
Huesa-Berral, C. (Carlos)|||/items/d2c35b31-4cf0-437c-aeff-d47b8a0f6fb6
Materias Investigacion::Física
Lung cancer
Radiotherapy
Stereotactic body radiation therapy
Cáncer de pulmón
Radioterapia
Radioterapia corporal estereotáctica
title_short Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
title_full Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
title_fullStr Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
title_full_unstemmed Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
title_sort Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy
dc.creator.none.fl_str_mv Huesa-Berral, C. (Carlos)|||/items/d2c35b31-4cf0-437c-aeff-d47b8a0f6fb6
author Huesa-Berral, C. (Carlos)|||/items/d2c35b31-4cf0-437c-aeff-d47b8a0f6fb6
author_facet Huesa-Berral, C. (Carlos)|||/items/d2c35b31-4cf0-437c-aeff-d47b8a0f6fb6
author_role author
dc.contributor.none.fl_str_mv Burguete-Mas, F.J. (Francisco Javier)
Azcona-Armendariz, J.D. (Juan Diego)
Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Materias Investigacion::Física
Lung cancer
Radiotherapy
Stereotactic body radiation therapy
Cáncer de pulmón
Radioterapia
Radioterapia corporal estereotáctica
topic Materias Investigacion::Física
Lung cancer
Radiotherapy
Stereotactic body radiation therapy
Cáncer de pulmón
Radioterapia
Radioterapia corporal estereotáctica
description Lung stereotactic body radiation therapy (SBRT) is associated with sources of geometric uncertainties, such as respiratory motion, daily anatomical variations (anatomical baseline shifts between daily and planned position) and the simultaneous movement between the tumor and the multileaf collimator (the so-called interplay effect) during treatment delivery. In this work, several methodologies have been implemented based on deformable image registration to quantify the dosimetric impact of those geometric uncertainties in lung SBRT. These methodologies revealed two main conclusions: First, daily anatomical deviations in patient anatomy generally had a larger dosimetric impact than respiratory motion. Second, the impact of interplay effect could be a concern for highly irregular patient breathing patterns or for long breathing periods, and whether small field size were used for dose conformation purposes. Furthermore, these methodologies developed would be very helpful for clinicians involved in treatment planning and delivery to evaluate treatment robustness against the geometric uncertainties studied in this work.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-09-13
2023
2023-01-23
2023
2023-01-23
2023
2023-01-23
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/65036
url https://hdl.handle.net/10171/65036
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad de Navarra
publisher.none.fl_str_mv Universidad de Navarra
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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